3'',5''-Difluoro-4''-Hydroxyacetophenone

Base Information

• Chemical Name: 3'',5''-Difluoro-4''-Hydroxyacetophenone
• CAS No.: 133186-55-7
• Molecular Formula: C8H6F2O2
• Molecular Weight: 172.131
• Hs Code.: 2914790090
• Mol file: 133186-55-7.mol

Synonyms:3'',5''-Difluoro-4''-Hydroxyacetophenone

Chemical Property of 3'',5''-Difluoro-4''-Hydroxyacetophenone

Chemical Property:

• PSA: 37.30000
• LogP: 1.87300
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Difluoro-4-hydroxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'',5''-Difluoro-4''-Hydroxyacetophenone

There total 5 articles about 3'',5''-Difluoro-4''-Hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(3,5-difluoro-4-methoxy-phenyl)ethanone (170570-79-3) → 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (133186-55-7)

Guidance literature:

With hydrogen bromide; In water; for 30h; Heating / reflux;

Reference yield: 73.0%

2',6'-difluorophenyl acetate (36914-78-0) → 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (133186-55-7)

Guidance literature:

With trifluorormethanesulfonic acid; at 40 ℃; for 16h; Cooling with ice;

DOI:10.1039/d1cc04408g

Reference yield:

2,6-difluorophenol (28177-48-2) → 1-(3,5-difluoro-4-hydroxyphenyl)ethanone (133186-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridine / toluene / 5 h

2: 52 percent / AlCl₃ / nitrobenzene / 5 h / 140 - 150 °C

With pyridine; aluminium trichloride; In nitrobenzene; toluene;

DOI:10.1016/0022-1139(93)02931-4

upstream raw materials:

2',6'-difluorophenyl acetate

4-Hydroxyacetophenone

1-(3,5-difluoro-4-methoxy-phenyl)ethanone

2,6-difluorophenol

Downstream raw materials:

4-(2-bromo-ethoxy)-3,5-difluoro-benzoic acid ethyl ester

1-[4-(2-bromo-ethoxy)-3,5-difluoro-phenyl]-ethanone

Refernces

• 1、 Cao, Wenwen,Li, Xiaoxin,Wu, Peng,Xiong, Hu. "Development of pH-activatable fluorescent probes for rapid visualization of metastatic tumours and fluorescence-guided surgeryviatopical spraying". supporting information. p. 10636 - 10639. Retrieved 2021/10/19.
• 2、 -. "Pyridizinone derivatives". Page/Page column 101. . Retrieved 2008/06/13.