Oxiranemethanol,alpha,3-bis(1-methylethyl)-,[2alpha(R*),3alpha]-(9CI)

Base Information

• Chemical Name: Oxiranemethanol,alpha,3-bis(1-methylethyl)-,[2alpha(R*),3alpha]-(9CI)
• CAS No.: 134175-92-1
• Molecular Formula: C9H18O2
• Molecular Weight: 158.241
• Mol file: 134175-92-1.mol

Synonyms:Oxiranemethanol,alpha,3-bis(1-methylethyl)-,[2alpha(R*),3alpha]-(9CI)

Chemical Property of Oxiranemethanol,alpha,3-bis(1-methylethyl)-,[2alpha(R*),3alpha]-(9CI)

Chemical Property:

• PSA: 32.76000
• LogP: 1.42670

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxiranemethanol,alpha,3-bis(1-methylethyl)-,[2alpha(R*),3alpha]-(9CI)

There total 3 articles about Oxiranemethanol,alpha,3-bis(1-methylethyl)-,[2alpha(R*),3alpha]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-1-lithio-2-lithiooxy-3-methylbutane (134111-25-4) + isobutyraldehyde (78-84-2) → 2-methyl-3-heptanol (18720-62-2) + 5-hydroxy-2,6-dimethyl-heptan-3-one (65429-68-7) + (3R*,4S*,5R*)-trans-4,5-epoxy-2,6-dimethyl-3-heptanol (134175-92-1,168399-37-9) + (3R*,4S*,5R*)-trans-4,5-epoxy-2,6-dimethyl-3-heptanol (134175-91-0,168399-37-9)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

Reference yield:

2,6-dimethyl-4-heptyn-3-ol (5923-00-2) → (3R*,4S*,5R*)-trans-4,5-epoxy-2,6-dimethyl-3-heptanol (134175-92-1,168399-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / H₂ / Lindlar catalyst / methanol / 2 h / Ambient temperature

2: vanadyl bis(acetylacetonate), tert-butyl hydroperoxide / CH₂Cl₂

With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; hydrogen; Lindlar's catalyst; In methanol; dichloromethane;

Reference yield:

(Z)-2,6-dimethyl-4-hepten-3-ol (134111-21-0) → (3R*,4S*,5R*)-trans-4,5-epoxy-2,6-dimethyl-3-heptanol (134175-92-1,168399-37-9) + (3R*,4S*,5R*)-trans-4,5-epoxy-2,6-dimethyl-3-heptanol (134175-91-0,168399-37-9)

Guidance literature:

With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; In dichloromethane; Title compound not separated from byproducts;

upstream raw materials:

(Z)-2,6-dimethyl-4-hepten-3-ol

1-bromo-1-lithio-2-lithiooxy-3-methylbutane

isobutyraldehyde

2,6-dimethyl-4-heptyn-3-ol