Pyrido[1,2-a]benzimidazole, 8-fluoro- (9CI)

Base Information

• Chemical Name: Pyrido[1,2-a]benzimidazole, 8-fluoro- (9CI)
• CAS No.: 136343-75-4
• Molecular Formula: C11H7FN2
• Molecular Weight: 186.1850832
• Mol file: 136343-75-4.mol

Synonyms:Pyrido[1,2-a]benzimidazole, 8-fluoro- (9CI)

Chemical Property of Pyrido[1,2-a]benzimidazole, 8-fluoro- (9CI)

Chemical Property:

• Melting Point: 182-183 °C
• Boiling Point: 276.1±33.0 °C(Predicted)
• PKA: 5.31±0.50(Predicted)
• PSA: 17.30000
• Density: 1.30±0.1 g/cm3(Predicted)
• LogP: 2.62660

Purity/Quality:

99% ，98% ^*data from raw suppliers

8-FLUORO-PYRIDO[1,2-A]BENZIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[1,2-a]benzimidazole, 8-fluoro- (9CI)

There total 18 articles about Pyrido[1,2-a]benzimidazole, 8-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(4-fluorophenyl)pyridin-2-ylamine (72358-70-4) → 8-fluoropyrido[1,2-a]benzimidazole (136343-75-4)

Guidance literature:

With [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In water; at 20 ℃; for 5h; regioselective reaction; Green chemistry;

DOI:10.1039/c4ra02279c

Reference yield: 95.0%

N-(4-fluorobenzyl)pyridine-2-amine (1692-02-0) → 8-fluoropyrido[1,2-a]benzimidazole (136343-75-4)

Guidance literature:

With bis(tertbutylcarbonyloxy)iodobenzene; at 25 ℃; for 7h;

DOI:10.1021/ol4015656

Reference yield: 80.0%

2-(2,4-Difluoroanilino)pyridine (136343-74-3) → 8-fluoropyrido[1,2-a]benzimidazole (136343-75-4)

Guidance literature:

With sodium hydroxide; In water; tert-butyl alcohol; for 7h; Irradiation;

upstream raw materials:

2-(2,4-Difluoroanilino)pyridine

(2-Chloro-4-fluoro-phenyl)-pyridin-2-yl-amine

2-bromo-pyridine

2,4-difluorophenylamine