N-(4-fluorophenyl)pyridin-2-amine

Base Information

• Chemical Name: N-(4-fluorophenyl)pyridin-2-amine
• CAS No.: 72358-70-4
• Molecular Formula: C11H9FN2
• Molecular Weight: 188.204
• European Community (EC) Number: 659-205-4
• Nikkaji Number: J2.961.281A
• Mol file: 72358-70-4.mol

Synonyms:72358-70-4;N-(4-fluorophenyl)pyridin-2-amine;2-(p-Fluoroanilino)pyridine;SCHEMBL904437;DSVOTYHSTIRRCO-UHFFFAOYSA-N;N-(4-fluorophenyl)-2-pyridinamine;N-(4-Fluorophenyl)pyridin-2-ylamine;AKOS022844041

Chemical Property of N-(4-fluorophenyl)pyridin-2-amine

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 188.07497646
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NC2=CC=C(C=C2)F

Technology Process of N-(4-fluorophenyl)pyridin-2-amine

There total 8 articles about N-(4-fluorophenyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloropyridine (109-09-1) + 4-fluoroaniline (371-40-4) → N-(4-fluorophenyl)pyridin-2-ylamine (72358-70-4)

Guidance literature:

With C₆₃H₅₄Cl₃N₃OPd; potassium 2-methylbutan-2-olate; In 1,4-dioxane; at 100 ℃; for 2h;

DOI:10.1021/acs.joc.6b02867

Reference yield: 99.0%

2-bromo-pyridine (109-04-6) + 4-fluoro-1-iodobenzene (352-34-1) → N-(4-fluorophenyl)pyridin-2-ylamine (72358-70-4)

Guidance literature:

4-fluoro-1-iodobenzene; With potassium phosphate; copper(l) iodide; lithium amide; In N,N-dimethyl-formamide; at 130 ℃; for 6h; Inert atmosphere;

2-bromo-pyridine; In N,N-dimethyl-formamide; at 130 ℃; for 18h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c2cc32252h

Reference yield: 88.0%

2-aminopyridine (504-29-0) + p-fluorothioanisole (371-15-3) → N-(4-fluorophenyl)pyridin-2-ylamine (72358-70-4)

Guidance literature:

With SingaCycle-A₁; potassium hexamethylsilazane; In toluene; at 100 ℃; for 18 - 24h; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0037-1611732

upstream raw materials:

2-chloropyridine

4-fluoroaniline

2-bromo-pyridine

4-fluoro-1-iodobenzene

Downstream raw materials:

(3-(N-4-fluorophenyl-N-pyridin-2-yl)-amino)-2-(di-tert-butyloxycarbonyl)-amino-propionic acid methyl ester