Carbamic acid, [3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-

Base Information

Chemical Name:Carbamic acid, [3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-
CAS No.:137105-99-8
Molecular Formula:C10H21NO4
Molecular Weight:219.281
Hs Code.:
Mol file:137105-99-8.mol

Synonyms:((1S,2S)-3-Hydroxy-1-hydroxymethyl-2-methyl-propyl)-carbamic acid tert-butyl ester;2(S)-[(t-butoxycarbonyl)amino]-3(S)-methylbutane-1,4-diol;

Suppliers and Price of Carbamic acid, [3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, [3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-

Chemical Property:

Melting Point:None °C
PSA：78.79000
LogP:0.89130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbamic acid, [3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-

There total 4 articles about Carbamic acid, [3-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 137105-99-8,734548-35-7
(2S,3S)-syn-2-tert-butoxycarbonylamino-3-methylbutane-1,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-bromosuccinimide

2.1: piperidinomethylpolystyrene / CH₂Cl₂ / 0.17 h / 20 °C

3.1: Cu(OTf)2; (R,R)-(o-MeC₆H₄-CH₂NHCHPh)2 / CH₂Cl₂ / 1 h / -20 °C

3.2: aq. HCl / tetrahydrofuran / 2 h / 20 °C

3.3: LiBNEt₃H / tetrahydrofuran / 0.5 h / 0 °C

With N-Bromosuccinimide; piperidinomethylpolystyrene; (1R,2R)-N,N’-bis(2-methylbenzyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; 3.1: Mannich-type reaction;
DOI:10.1021/ol034717d

Reference yield:

: 137172-54-4
3(S)-[(t-butoxycarbonyl)amino]-2(S)-methyl - γ-butyrolactone

: 137105-99-8,734548-35-7
(2S,3S)-syn-2-tert-butoxycarbonylamino-3-methylbutane-1,4-diol

Guidance literature:: With sodium borohydrid; citric acid; lithium chloride; In tetrahydrofuran; ethanol;

Reference yield:

: 76943-94-7
(Z)-1-(tert-butylthio)-1-trimethylsilyloxyprop-1-ene

: 81357-15-5
[(E)-tert-Butoxycarbonylimino]-acetic acid methyl ester

: 137106-00-4,734548-35-7
(2R,3R)-(3-hydroxy-1-hydroxymethyl-2-methyl-propyl)-carbamic acid tert-butyl ester

: 137105-99-8,734548-35-7
(2S,3S)-syn-2-tert-butoxycarbonylamino-3-methylbutane-1,4-diol

: 734548-35-7
anti-2-tert-butoxycarbonylamino-3-methylbutane-1,4-diol

Guidance literature:: (Z)-1-(tert-butylthio)-1-trimethylsilyloxyprop-1-ene; [(E)-tert-Butoxycarbonylimino]-acetic acid methyl ester; With (1R,2R)-N,N’-bis(2-methylbenzyl)-1,2-diphenylethane-1,2-diamine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at -20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h;

With LiBNEt₃H; In tetrahydrofuran; at 0 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1021/ol034717d