BROMO-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]ACETIC ACID METHYL ESTER

Base Information

• Chemical Name: BROMO-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]ACETIC ACID METHYL ESTER
• CAS No.: 138219-39-3
• Molecular Formula: C8H14BrNO4
• Molecular Weight: 268.107
• Hs Code.: 2924199090
• Mol file: 138219-39-3.mol

Synonyms:BROMO-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]ACETIC ACID METHYL ESTER

Chemical Property of BROMO-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]ACETIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: 1.479
• Boiling Point: 301.6°Cat760mmHg
• Flash Point: 136.2°C
• PSA: 64.63000
• Density: 1.411g/cm³
• LogP: 1.79600

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BROMO-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]ACETIC ACID METHYL ESTER

There total 1 articles about BROMO-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]ACETIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5) → 2-bromo-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester (138219-39-3)

Guidance literature:

With N-Bromosuccinimide; In dimethyl sulfoxide; at 10 - 30 ℃; for 1h; Irradiation;

Reference yield: 53.0%

diphenylmethane tricarbonylchromium (32825-32-4) + 2-bromo-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester (138219-39-3) → [Cr(CO)3(C6H5CH(C6H5)CH(CO2CH3)NHCO2C(CH3)3)] (188296-15-3)

Guidance literature:

With KH; In tetrahydrofuran; (argon); addn. of KH to the Cr-complex in THF at room temp., stirring (2h), cooling to -78°C, addn. to the glycine derivative in THF, st irring (1 h), warming to room temp.; evapn., addn. of CH2Cl2, filtration (silica; Et2O), evapn., stirring with pentane at -20°C, drying (vac.); elem. anal.;

DOI:10.1002/cber.19971300206

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) + 2-bromo-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester (138219-39-3) → 4-(2-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-benzoic acid methyl ester

Guidance literature:

With 3,4,7,8-Tetramethyl-o-phenanthrolin; Ni⁽²⁺⁾*2C₄H₅O₃^(1-); lithium iodide; zinc; In acetonitrile; at 60 ℃;

DOI:10.1021/acscatal.1c04239

upstream raw materials:

N-(tert-butoxycarbonyl)glycine methyl ester

Downstream raw materials:

2-tert-Butoxycarbonylamino-but-3-enoic acid methyl ester

(RS)-2-(1-benzyloxy-4-pyrazolyl)-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester

(RS)-2-(1-benzyloxy-4-pyrazolyl)-2-(N-tert-butoxycarbonylamino)acetic acid

(RS)-2-(1-benzyloxy-5-bromo-4-pyrazolyl)-2-(N-tert-butoxycarbonylamino)acetic acid methyl ester