2-Methyl-1,2,6-thiadiazinane 1,1-dioxide

Base Information

• Chemical Name: 2-Methyl-1,2,6-thiadiazinane 1,1-dioxide
• CAS No.: 137830-77-4
• Molecular Formula: C4H10N2O2S
• Molecular Weight: 150.2
• Hs Code.: 2933990090
• European Community (EC) Number: 864-578-3
• DSSTox Substance ID: DTXSID10435223
• Wikidata: Q82250002
• Mol file: 137830-77-4.mol

Synonyms:2-methyl-1,2,6-thiadiazinane 1,1-dioxide;137830-77-4;2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide;2H-1,2,6-Thiadiazine, tetrahydro-2-methyl-, 1,1-dioxide;SCHEMBL4061960;DTXSID10435223;BXAHKRQLBBUNGK-UHFFFAOYSA-N;MFCD06657763;AKOS006293381;CS-W006251;DS-16261;2-Methyl-1,2,6-thiadiazinane-1,1-dioxide;EN300-246049;2-methyl-1lambda6,2,6-thiadiazinane-1,1-dione;A886394;2-Methyl-1lambda~6~,2,6-thiadiazinane-1,1-dione;2-methyl-tetrahydro-1,2,6-thiadiazine-1,1-dioxide;J-007063;2-METHYL-1??,2,6-THIADIAZINANE-1,1-DIONE;Z1198169375

Chemical Property of 2-Methyl-1,2,6-thiadiazinane 1,1-dioxide

Chemical Property:

• PSA: 57.79000
• LogP: 0.50380
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: -0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 150.04629874
• Heavy Atom Count: 9
• Complexity: 181

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Methyl-1,2,6-thiadiazinane1,1-dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCNS1(=O)=O

Technology Process of 2-Methyl-1,2,6-thiadiazinane 1,1-dioxide

There total 2 articles about 2-Methyl-1,2,6-thiadiazinane 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-Methyl-1,3-propanediamine (6291-84-5) → 2-methyl-3,4,5,6-tetrahydro-1,2,6-thiadiazine-1,1-dioxide (137830-77-4)

Guidance literature:

With SULFAMIDE; In pyridine; for 16h;

DOI:10.1021/jm00045a006

Reference yield:

SULFAMIDE (7803-58-9) + N-Methyl-1,3-propanediamine (6291-84-5) → 2-methyl-3,4,5,6-tetrahydro-1,2,6-thiadiazine-1,1-dioxide (137830-77-4)

Guidance literature:

With pyridine; for 16h; Reflux;

DOI:10.1016/j.bmcl.2008.09.034

Reference yield: 55.0%

2-methyl-3,4,5,6-tetrahydro-1,2,6-thiadiazine-1,1-dioxide (137830-77-4) + (2S,4S)-2-mesyloxymethyl-4-tritylthio-1-(allyloxycarbonyl)pyrrolidine (137934-48-6) → (C6H5)3CSCH2CHCH2OCOC4H6NCH2N2C3H6SO2CH3

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2007.02.001

upstream raw materials:

N-Methyl-1,3-propanediamine

SULFAMIDE

Downstream raw materials:

C₁₀H₁₂FN₃O₄S

C₃₂H₃₅N₃O₅S₂

Refernces

• 1、 Humphries, Paul S.,Bersot, Ross,Kincaid, John,Mabery, Eric,McCluskie, Kerryn,Park, Timothy,Renner, Travis,Riegler, Erin,Steinfeld, Tod,Turtle, Eric D.,Wei, Zhi-Liang,Willis, Erik. "Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents". . p. 757 - 760. Retrieved 2016/05/24.
• 2、 -. "HETEROARYLS AND USES THEREOF". Paragraph 0555-0556. . Retrieved 2015/09/22.