137934-48-6Relevant articles and documents
Novel lβ-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity
Kim, Seong Jong,Park, Hyeong Beom,Lee, Jae Seoung,Jo, Nam Hyun,Yoo, Kyung Ho,Baek, Daejin,Kang, Byoung-won,Cho, Jung-Hyuck,Oh, Chang-Hyun
, p. 1176 - 1183 (2007)
The synthesis of a new series of 1β-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidi
Synthesis and Antibacterial Activity of 1β-Methyl-2-(5-substituted oxadiazolo pyrrolidin-3-yl-thio)carbapenem Derivatives
Oh, Chang-Hyun,Dong, Hyun-Gu,Lee, Joo-Shin,Lee, Su-Chul,Hong, Joon Hee,Cho, Jung-Hyuck
, p. 567 - 572 (2007/10/03)
Synthesis of a new series of 1β-methylcarbapenems with a substituted oxadiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of the substituent on
2-(substituted pyrrolidinylthio)carbapenem derivatives
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, (2008/06/13)
A compound of the formula: STR1 wherein R is a hydrogen atom or a methyl group, R1 is a hydrogen atom or a negative charge, each of R2 and R3 which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, --COOR4, --CON(R5)R6, --N(R5)R6, --CH2 COOR4, --CH2 N(R5)R6 or --CH2 CON(R5)R6 (wherein R4 is a hydrogen atom or a lower alkyl group, each of R5 and R6 which may be the same or different, is a hydrogen atom or a lower alkyl group, or R5 and R6 form together with the adjacent nitrogen atom a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group and a piperidyl group), A is =NR7, =N+ (R7)R8, wherein each of R7 and R8 which may be the same or different, is a hydrogen atom, a lower alkyl group, a hydroxy lower alkyl group, a formimidoyl group, an acetoimidoyl group, --COOR4, --CON(R5)R6, --N(R5)R6, --CH2 COOR4, --CH2 N(R5)R6 or --CH2 CON(R5)R6 (wherein R4, R5 and R6 are as defined above), p is an integer of from 0 to 3, and q is an integer of from 1 to 3; or a pharmaceutically acceptable salt or ester thereof.