4,5-Dimethoxy-2-methyl-indan-1-one

Base Information

Chemical Name:4,5-Dimethoxy-2-methyl-indan-1-one
CAS No.:138261-10-6
Molecular Formula:C₁₂H₁₄O₃
Molecular Weight:206.241
Hs Code.:2914509090
ChEMBL ID:CHEMBL155371
DSSTox Substance ID:DTXSID20566719
Nikkaji Number:J460.210B
Pharos Ligand ID:8RAJXTA62W92
Mol file:138261-10-6.mol

Synonyms:4,5-Dimethoxy-2-methyl-indan-1-one;138261-10-6;4,5-DIMETHOXY-2-METHYL-2,3-DIHYDROINDEN-1-ONE;CHEMBL155371;4,5-Dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one;DTXSID20566719;BDBM50008559;AKOS015964151;N14239

Suppliers and Price of 4,5-Dimethoxy-2-methyl-indan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4,5-DIMETHOXY-2-METHYL-INDAN-1-ONE 95.00%
5MG
$ 498.54

Total 1 raw suppliers

Chemical Property of 4,5-Dimethoxy-2-methyl-indan-1-one

Chemical Property:

Vapor Pressure:3.92E-05mmHg at 25°C
Melting Point:69-70 °C(Solv: ethyl ether (60-29-7))
Refractive Index:1.53
Boiling Point:352.1°C at 760 mmHg
Flash Point:158°C
PSA：35.53000
Density:1.126g/cm³
LogP:2.07870
XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:206.094294304
Heavy Atom Count:15
Complexity:251

Purity/Quality:: 4,5-DIMETHOXY-2-METHYL-INDAN-1-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC2=C(C1=O)C=CC(=C2OC)OC

Technology Process of 4,5-Dimethoxy-2-methyl-indan-1-one

There total 7 articles about 4,5-Dimethoxy-2-methyl-indan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 4-hydroxy-5-methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

: 74-88-4
methyl iodide

: 138261-10-6
4,5-dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Guidance literature:: With potassium carbonate; In ethanol; for 2h; Reflux; Inert atmosphere;
DOI:10.1055/s-0037-1611711

Reference yield: 75.0%

: 848610-85-5
5-(2,3-dimethoxybenzyl)-2,2,5-trimethyl-1,3-dioxane-4,6-dione

: 138261-10-6
4,5-dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In nitromethane; at 100 ℃; for 0.333333h;
DOI:10.1021/jo0483724

Reference yield:

: 848610-54-8
5-(2,3-dimethoxybenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 138261-10-6
4,5-dimethoxy-2-methyl-2,3-dihydro-1H-inden-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / K₂CO₃ / dimethylformamide

2: 75 percent / Sc(OTf)3 / nitromethane / 0.33 h / 100 °C

With potassium carbonate; scandium tris(trifluoromethanesulfonate); In nitromethane; N,N-dimethyl-formamide; 2: Friedel-Crafts acylation;
DOI:10.1021/jo0483724