3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-,methylester,(3S)-(9CI)

Base Information

• Chemical Name: 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-,methylester,(3S)-(9CI)
• CAS No.: 138323-06-5
• Molecular Formula: C6H10N2O2
• Molecular Weight: 142.158
• Mol file: 138323-06-5.mol

Synonyms:3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-,methylester,(3S)-(9CI)

Chemical Property of 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-,methylester,(3S)-(9CI)

Chemical Property:

• PSA: 50.69000
• LogP: -0.33840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-,methylester,(3S)-(9CI)

There total 6 articles about 3-Pyridazinecarboxylicacid,2,3,4,5-tetrahydro-,methylester,(3S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl (3S,6S)-1,2-bis(benzyloxycarbonyl)-1,2,3,6-tetrahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate (252039-93-3) → Methyl pyridazine-3-carboxylate (34253-02-6) + 2,3,4,5-tetra-O-acetyl-D-glucopyranose (3947-62-4,6207-76-7,19235-21-3,22554-70-7,22860-22-6,47339-09-3,57884-82-9,62057-79-8,70191-05-8,109525-54-4,140147-37-1,10343-06-3) + Methyl (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylate (138323-06-5,193528-27-7)

Guidance literature:

palladium on activated charcoal; for 1.5h;

Reference yield: 95.0%

methyl (S)-<1,2-bis(t-butoxycarbonyl)hydrazino>-5,5-dimethoxypentanoate (138323-05-4) → Methyl (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylate (138323-06-5,193528-27-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1246/cl.1991.1953

Reference yield: 57.0%

Methyl (3S,6S)-1,2-bis(tert-butoxycarbonyl)-1,2,3,4,5,6-hexahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate (153118-51-5) → 2,3,4,5-tetra-O-acetyl-D-glucopyranose (3947-62-4,6207-76-7,19235-21-3,22554-70-7,22860-22-6,47339-09-3,57884-82-9,62057-79-8,70191-05-8,109525-54-4,140147-37-1,10343-06-3) + Methyl (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylate (138323-06-5,193528-27-7)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1039/c39930001179

upstream raw materials:

methyl (S)-<1,2-bis(t-butoxycarbonyl)hydrazino>-5,5-dimethoxypentanoate

Methyl (3S,6S)-1,2-bis(tert-butoxycarbonyl)-1,2,3,4,5,6-hexahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate

Methyl (3S,6S)-1,2-bis(benzyloxycarbonyl)-1,2,3,6-tetrahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate

Methyl (3S,6S)-1,2-bis(tert-butoxycarbonyl)-1,2,3,6-tetrahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate

Downstream raw materials:

Methyl (3S)-1-(2,4-dinitrophenyl)-1,2,3,4,5,6-hexahydropyridazine-3-carboxylate

methyl (S)-hexahydropyridazine-3-carboxylate