Methyl pyridazine-3-carboxylate

Base Information

• Chemical Name: Methyl pyridazine-3-carboxylate
• CAS No.: 34253-02-6
• Molecular Formula: C6H6N2O2
• Molecular Weight: 138.126
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30515076
• Nikkaji Number: J396.456F
• Wikidata: Q72496461
• Mol file: 34253-02-6.mol

Synonyms:Methyl pyridazine-3-carboxylate;34253-02-6;3-pyridazinecarboxylic acid methyl ester;MFCD10698044;3-PYRIDAZINECARBOXYLIC ACID, METHYL ESTER;PYRIDAZINE-3-CARBOXYLIC ACID METHYL ESTER;Methylpyridazine-3-carboxylate;SCHEMBL6602091;DTXSID30515076;BCP22431;AKOS015949992;PB28168;AC-28826;DS-16862;SY034369;AM20090523;CS-0044033;FT-0684730;A822136;J-522631;F2147-1909

Chemical Property of Methyl pyridazine-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Melting Point: 139 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 281.273oC at 760 mmHg
• PKA: 0.77±0.10(Predicted)
• Flash Point: 123.91oC
• PSA: 52.08000
• Density: 1.214g/cm3
• LogP: 0.26320
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 138.042927438
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

97% ^*data from raw suppliers

MethylPyridazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=NN=CC=C1

Technology Process of Methyl pyridazine-3-carboxylate

There total 1 articles about Methyl pyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl (3S,6S)-1,2-bis(benzyloxycarbonyl)-1,2,3,6-tetrahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate (252039-93-3) → Methyl pyridazine-3-carboxylate (34253-02-6) + 2,3,4,5-tetra-O-acetyl-D-glucopyranose (3947-62-4,6207-76-7,19235-21-3,22554-70-7,22860-22-6,47339-09-3,57884-82-9,62057-79-8,70191-05-8,109525-54-4,140147-37-1,10343-06-3) + Methyl (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylate (138323-06-5,193528-27-7)

Guidance literature:

palladium on activated charcoal; for 1.5h;

Reference yield: 80.0%

Methyl pyridazine-3-carboxylate (34253-02-6) → Pyridazine-3-carboxyamide (5450-54-4)

Guidance literature:

With ammonia; In tetrahydrofuran; at 50 ℃; for 12h; Inert atmosphere;

Reference yield: 10.0%

Methyl pyridazine-3-carboxylate (34253-02-6) → pyridazine-3-carbohydrazide (89463-74-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃;

DOI:10.1002/anie.201608813

upstream raw materials:

Methyl (3S,6S)-1,2-bis(benzyloxycarbonyl)-1,2,3,6-tetrahydro-6-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranosyloxy)pyridazine-3-carboxylate

Downstream raw materials:

Pyridazine-3-carboxyamide

methyl 2-(dimethylamino)benzoate

2-Diethylamino-3-tolylsaeuremethylester

5-chloro-2-(methylamino)phenyl 3-pyridazinyl ketone