6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 697739-05-2
• Molecular Formula: C₉H₇FN₂O₂
• Molecular Weight: 194.165
• Mol file: 697739-05-2.mol

Synonyms:Methyl6-fluoro-1H-indazole-4-carboxylate

Chemical Property of 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 357.6±27.0 °C(Predicted)
• PKA: 11?+-.0.40(Predicted)
• PSA: 54.98000
• Density: 1.415±0.06 g/cm3(Predicted)
• LogP: 1.48860

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-fluoro-1H-indazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER

There total 3 articles about 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methanol (67-56-1) + 6-fluoro-1H-indole-4-carboxylic acid hydrazide → methyl 6-fluoro-1H-indazole-4-carboxylate (697739-05-2)

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; at 40 ℃;

Reference yield: 27.0%

3-amino-5-fluoro-2-methylbenzoic acid methyl ester (697739-04-1) → methyl 6-fluoro-1H-indazole-4-carboxylate (697739-05-2)

Guidance literature:

3-amino-5-fluoro-2-methylbenzoic acid methyl ester; With hydrogenchloride; ammonium tetrafluroborate; sodium nitrite; In water; at 0 ℃; for 0.666667h;

With 18-crown-6 ether; potassium acetate; In chloroform; at 20 ℃; for 1h;

Reference yield:

→ methyl 6-fluoro-1H-indazole-4-carboxylate (697739-05-2)

Guidance literature:

upstream raw materials:

3-amino-5-fluoro-2-methylbenzoic acid methyl ester

methanol