2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone

Base Information

Chemical Name:2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone
CAS No.:139607-68-4
Molecular Formula:C10H10ClNO2
Molecular Weight:211.6449
Hs Code.:
DSSTox Substance ID:DTXSID90577812
Wikidata:Q82467915
Mol file:139607-68-4.mol

Synonyms:139607-68-4;2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone;1H-Indol-5-ol, 1-(chloroacetyl)-2,3-dihydro- (9CI);2-chloro-1-(5-hydroxy-2,3-dihydroindol-1-yl)ethanone;2-Chloro-1-(5-hydroxy-2,3-dihydro-1H-indol-1-yl)ethan-1-one;2-chloro-1-(5-hydroxy-2,3-dihydro-indol-1-yl)-ethanone;DTXSID90577812;InChI=1/C10H10ClNO2/c11-6-10(14)12-4-3-7-5-8(13)1-2-9(7)12/h1-2,5,13H,3-4,6H

Suppliers and Price of 2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone

Chemical Property:

PSA：40.54000
LogP:1.58510
XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:211.0400063
Heavy Atom Count:14
Complexity:234

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C2=C1C=C(C=C2)O)C(=O)CCl

Technology Process of 2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone

There total 3 articles about 2-Chloro-1-(5-hydroxyindolin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139607-67-3
1-(chloroacetyl)-5-methoxyindoline

: 50525-92-3
7-hydroxy-4,5-dihydro-1H-pyrrolo<3,2,1-hi>indol-2-one

: 139607-68-4
2-Chloro-1-(5-hydroxy-2,3-dihydro-indol-1-yl)-ethanone

Guidance literature:: With aluminium trichloride; at 360 - 370 ℃; for 0.0666667h;
DOI:10.1021/jo00034a062

Reference yield:

: 1006-94-6
5-methoxylindole

: 139607-68-4
2-Chloro-1-(5-hydroxy-2,3-dihydro-indol-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / NaBH₃CN, acetic acid

2: 95 percent / K₂CO₃ / CHCl₃ / 1.5 h / Ambient temperature

3: 153 mg / AlCl₃ / 0.07 h / 360 - 370 °C

With aluminium trichloride; sodium cyanoborohydride; potassium carbonate; acetic acid; In chloroform;
DOI:10.1021/jo00034a062

Reference yield:

: 21857-45-4
5-methoxyindoline

: 139607-68-4
2-Chloro-1-(5-hydroxy-2,3-dihydro-indol-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / K₂CO₃ / CHCl₃ / 1.5 h / Ambient temperature

2: 153 mg / AlCl₃ / 0.07 h / 360 - 370 °C

With aluminium trichloride; potassium carbonate; In chloroform;
DOI:10.1021/jo00034a062