2-IODO-5'-ETHYLCARBOXAMIDOADENOSINE

Base Information

• Chemical Name: 2-IODO-5'-ETHYLCARBOXAMIDOADENOSINE
• CAS No.: 141018-29-3
• Molecular Formula: C12H15 I N6 O4
• Molecular Weight: 434.193
• Mol file: 141018-29-3.mol

Synonyms:5'-Ethylcarboxamido-2-iodo-D-adenosine

Chemical Property of 2-IODO-5'-ETHYLCARBOXAMIDOADENOSINE

Chemical Property:

• Melting Point: 218-220°C
• PKA: 12.87±0.70(Predicted)
• PSA: 157.64000
• Density: 2.38±0.1 g/cm3(Predicted)
• LogP: 0.35050
• Storage Temp.: -20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

2-Iodo-5’-ethylcarboxamidoAdenosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Iodo-5’-ethylcarboxamido Adenosine is a potent and selective adenosine receptor agonist (1,2). 2-Iodo-5’-ethylcarboxamido Adenosine can be used to determine binding and structural properties between receptor subtypes.

Technology Process of 2-IODO-5'-ETHYLCARBOXAMIDOADENOSINE

There total 7 articles about 2-IODO-5'-ETHYLCARBOXAMIDOADENOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-ethyl-1'-deoxy-1'-(6-amino-2-iodo-9H-purin-9-yl)-2',3'-O-isopropylidene-β-D-ribofuranuronamide (162936-24-5) → 2-iodo-5'-N-ethylcarboxamidoadenosine (141018-29-3)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 1.08333h;

Reference yield: 85.0%

ethylamine (75-04-7,85404-22-4) + ethyl 1'-deoxy-1'-(6-amino-2-iodo-9H-purin-9-yl)-β-D-ribofuranuronate (141018-28-2) → 2-iodo-5'-N-ethylcarboxamidoadenosine (141018-29-3)

Guidance literature:

at -20 - 20 ℃;

DOI:10.1021/jm00091a003

Reference yield: 72.0%

1'-deoxy-1'-(6-amino-2-iodo-9H-purin-9-yl)-β-D-ribofuranuroic acid (141018-27-1) → 2-iodo-5'-N-ethylcarboxamidoadenosine (141018-29-3)

Guidance literature:

1'-deoxy-1'-(6-amino-2-iodo-9H-purin-9-yl)-β-D-ribofuranuroic acid; With thionyl chloride; In ethanol; at 0 - 20 ℃;

With sodium hydrogencarbonate; In ethanol; water; pH 8;

With ethylamine; at -20 - 20 ℃;

upstream raw materials:

ethylamine

ethyl 1'-deoxy-1'-(6-amino-2-iodo-9H-purin-9-yl)-β-D-ribofuranuronate

2-iodoadenosine

(3aR,4R,6R,6aR)-(6-(6-amino-2-iodo-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

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