1-{4-[(Pyridin-3-yl)methyl]morpholin-2-yl}methanamine

Base Information

• Chemical Name: 1-{4-[(Pyridin-3-yl)methyl]morpholin-2-yl}methanamine
• CAS No.: 141815-43-2
• Molecular Formula: C₁₁H₁₇N₃O
• Molecular Weight: 207.275
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00585726
• Mol file: 141815-43-2.mol

Synonyms:141815-43-2;[4-(pyridin-3-ylmethyl)morpholin-2-yl]methanamine;1-{4-[(Pyridin-3-yl)methyl]morpholin-2-yl}methanamine;C-(4-PYRIDIN-3-YLMETHYL-MORPHOLIN-2-YL)-METHYLAMINE TRIHYDROCHLORIDE;DTXSID00585726;AKOS010593865

Chemical Property of 1-{4-[(Pyridin-3-yl)methyl]morpholin-2-yl}methanamine

Chemical Property:

• PSA: 51.38000
• LogP: 3.28530
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 207.137162174
• Heavy Atom Count: 15
• Complexity: 189

Purity/Quality:

98%min ^*data from raw suppliers

C-(4-PYRIDIN-3-YLMETHYL-MORPHOLIN-2-YL)-METHYLAMINE TRIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1CC2=CN=CC=C2)CN

Technology Process of 1-{4-[(Pyridin-3-yl)methyl]morpholin-2-yl}methanamine

There total 3 articles about 1-{4-[(Pyridin-3-yl)methyl]morpholin-2-yl}methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N-acetylaminomethyl)-4-benzylmorpholine (112913-96-9) → C-(4-Pyridin-3-ylmethyl-morpholin-2-yl)-methylamine (141815-43-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol; acetic acid / 60 °C

2: K₂CO₃, KI / butan-2-one / 17 h / Heating

3: 10percent HCl / 4 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; acetic acid; butanone;

DOI:10.1248/cpb.40.652

Reference yield:

2-(N-acetylaminomethyl)morpholine (112913-95-8) → C-(4-Pyridin-3-ylmethyl-morpholin-2-yl)-methylamine (141815-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, KI / butan-2-one / 17 h / Heating

2: 10percent HCl / 4 h / Heating

With hydrogenchloride; potassium carbonate; potassium iodide; In butanone;

DOI:10.1248/cpb.40.652

Reference yield:

N-(4-Pyridin-3-ylmethyl-morpholin-2-ylmethyl)-acetamide (112886-83-6) → C-(4-Pyridin-3-ylmethyl-morpholin-2-yl)-methylamine (141815-43-2)

Guidance literature:

With hydrogenchloride; for 4h; Heating;

DOI:10.1248/cpb.40.652

upstream raw materials:

N-(4-Pyridin-3-ylmethyl-morpholin-2-ylmethyl)-acetamide

2-(N-acetylaminomethyl)-4-benzylmorpholine

2-(N-acetylaminomethyl)morpholine