(2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90%

Base Information

• Chemical Name: (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90%
• CAS No.: 147501-85-7
• Molecular Formula: C₅H₁₀O₄
• Molecular Weight: 134.132
• Mol file: 147501-85-7.mol

Synonyms:Propanoicacid, 2,3-dihydroxy-2-methyl-, methyl ester, (S)-; Methyl(S)-2,3-dihydroxy-2-methylpropionate

Chemical Property of (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90%

Chemical Property:

• Vapor Pressure: 0.00779mmHg at 25°C
• Refractive Index: 1.46
• Boiling Point: 237.9°C at 760 mmHg
• Flash Point: 99.6°C
• PSA: 66.76000
• Density: 1.223g/cm³
• LogP: -1.09730
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

(2S)-2,3-Dihydroxy-2-methyl-propanoicAcidMethylEster90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90% (cas# 147501-85-7) is a compound useful in organic synthesis.

Technology Process of (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90%

There total 4 articles about (2S)-2,3-Dihydroxy-2-methyl-propanoic Acid Methyl Ester 90% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (S)-2,3-dihydroxy-2-methyl-propionic acid (316373-88-3) → (S)-2,3-dihydroxy-2-methyl-propionic acid methyl ester (147501-85-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/S0957-4166(00)86020-6

Reference yield: 90.0%

methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → (S)-2,3-dihydroxy-2-methyl-propionic acid methyl ester (147501-85-7)

Guidance literature:

With potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; (9S,9"S)-9,9"-[phthalazine-1,4-diylbis-(oxy)]bis[10,11-dihydro-6'-methoxycinchonane]; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃; enantioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201403622

Reference yield:

methanol (67-56-1) + Weinreb amide of 2-methyl-2-propeonic acid (132960-14-6) → (S)-2,3-dihydroxy-2-methyl-propionic acid methyl ester (147501-85-7) + (R)-2,3-dihydroxy-2-methyl-propionic acid methyl ester (147501-89-1)

Guidance literature:

Weinreb amide of 2-methyl-2-propeonic acid; With potassium osmate; methanesulfonamide; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 - 20 ℃;

With lithium hydroxide; In methanol; water; at 20 ℃; for 5h;

methanol; With acetyl chloride; Title compound not separated from byproducts; Heating;

DOI:10.1021/ol034025p

upstream raw materials:

diazomethane

(S)-2,3-dihydroxy-2-methyl-propionic acid

methanol

Weinreb amide of 2-methyl-2-propeonic acid

Downstream raw materials:

(S)-3-Azido-2-hydroxy-2-methyl-propionic acid methyl ester

(R)-2-azido-3-hydroxy-2-methyl-propionic acid methyl ester

(4S)-4-methyl-2-oxo-2λ⁴-[1,3,2]dioxathiolane-4-carboxylic acid methyl ester