2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)

Base Information

• Chemical Name: 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)
• CAS No.: 148507-73-7
• Molecular Formula: C₄H₆O₆*C₁₅H₂₅NO₃
• Molecular Weight: 417.456
• Mol file: 148507-73-7.mol

Synonyms:2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (2S)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1) (salt) (9CI);2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)

Chemical Property of 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt)

There total 3 articles about 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (S)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (2:1) (salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(RS)-metoprolol (51384-51-1,37350-58-6) + tartaric acid (87-69-4,138508-61-9) → metoprolol tartrate (56392-17-7,74220-04-5,80416-08-6,80551-63-9,126794-42-1,129947-83-7,131478-70-1,148507-72-6,148507-73-7)

Guidance literature:

In acetone; for 4h; pH=6.2; Heating / reflux;

Reference yield:

4-(2-methoxyethyl)phenol (56718-71-9) → metoprolol tartrate (56392-17-7,74220-04-5,80416-08-6,80551-63-9,126794-42-1,129947-83-7,131478-70-1,148507-72-6,148507-73-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water / 3 - 5 h / 40 - 45 °C

2: water / 3 h / 0 - 30 °C

3: acetone / 4 h / pH 6.2 / Heating / reflux

With sodium hydroxide; In water; acetone;

Reference yield:

→ metoprolol tartrate (56392-17-7,74220-04-5,80416-08-6,80551-63-9,126794-42-1,129947-83-7,131478-70-1,148507-72-6,148507-73-7)

Guidance literature:

upstream raw materials:

(RS)-metoprolol

tartaric acid

4-(2-methoxyethyl)phenol

Downstream raw materials:

N-nitrosometoprolol

C₁₅H₂₄⁽¹²⁵⁾INO₃