5-Thiazolecarbonyl chloride, 2-chloro- (9CI)

Base Information

• Chemical Name: 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)
• CAS No.: 148637-74-5
• Molecular Formula: C4H Cl2 N O S
• Molecular Weight: 182.03
• Hs Code.: 2934100090
• Mol file: 148637-74-5.mol

Synonyms:2-Chlorothiazole-5-carbonylchloride

Chemical Property of 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)

Chemical Property:

• Vapor Pressure: 0.00386mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 280.1°C at 760 mmHg
• PKA: -1.67±0.10(Predicted)
• Flash Point: 123.2°C
• PSA: 58.20000
• Density: 1.647g/cm³
• LogP: 2.17550

Purity/Quality:

99% ^*data from raw suppliers

2-chloro-1,3-thiazole-5-carbonylchloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)

There total 2 articles about 5-Thiazolecarbonyl chloride, 2-chloro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-1,3-thiazole-5-carboxylic acid (101012-12-8) → 2-chloro-1,3-thiazole-5-carbonyl chloride (148637-74-5)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

2-bromo-thiazole-5-carboxylic acid (54045-76-0) → 2-chloro-1,3-thiazole-5-carbonyl chloride (148637-74-5)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In ethyl acetate; at 65 ℃; for 2h;

Reference yield: 60.0%

2-chloro-1,3-thiazole-5-carbonyl chloride (148637-74-5) + 2-chloro-6-methylaniline (87-63-8) → 2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide (302964-11-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

2-bromo-thiazole-5-carboxylic acid

2-chloro-1,3-thiazole-5-carboxylic acid

Downstream raw materials:

ethyl 2-chloro-thiazole-5-carboxylate

2-chloro-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

Refernces

• 1、 Palmer, Nick,Peakman, Torren M.,Norton, David,Rees, David C.. "Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)". . p. 1599 - 1610. Retrieved 2016/02/10.
• 2、 -. "HETEROCYCLIC AMINO BERBAMINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF". Paragraph 0095; 0099. . Retrieved 2013/07/25.