5-Fluoro-2,3-dihydro-1H-inden-1-amine

Base Information

• Chemical Name: 5-Fluoro-2,3-dihydro-1H-inden-1-amine
• CAS No.: 148960-33-2
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.184
• DSSTox Substance ID: DTXSID90586580
• Mol file: 148960-33-2.mol

Synonyms:148960-33-2;5-FLUORO-2,3-DIHYDRO-1H-INDEN-1-AMINE;1H-Inden-1-amine, 5-fluoro-2,3-dihydro-;148960-39-8;5-FLUORO-INDAN-1-YLAMINE;1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO;(1S)-1-Amino-5-fluoroindane;1H-Inden-1-amine,5-fluoro-2,3-dihydro-,(-)-(9CI);rac-5-fluoro-indan-1-ylamine;5-fluoro-1-aminoindan;1-amino-5-fluoro-indane;(5-Fluoro-indan-1-yl)amine;SCHEMBL354134;(rs)-5-fluoro-indane-1-ylamine;DTXSID90586580;POTIEZMRLKEJOZ-UHFFFAOYSA-N;1H-INDEN-1-AMINE, 5-FLUORO-2,3-DIHYDRO-, (-)-;AM761;MFCD07373914;AKOS000204996;AKOS016042424;AB29094;AB29097;AB38284;MCULE-5280996051;SB75993;AS-78232;DB-063784;(5-Fluoro-2,3-dihydro-1H-inden)-1-amine;EN300-58767;(-)-5-Fluoro-2,3-dihydro-1H-inden-1-amine;Y11814;AB01004596-01;A852415;(5-Fluoroindan-1-yl)amine;1-Amino-5-fluoroindan;5-Fluoro-2,3-dihydro-1H-Inden-1-amine;5-Fluoro-2,3-dihydro-1H-inden-1-ylamine

Chemical Property of 5-Fluoro-2,3-dihydro-1H-inden-1-amine

Chemical Property:

• Boiling Point: 222.8±40.0 °C(Predicted)
• PKA: 9.16±0.20(Predicted)
• PSA: 26.02000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 2.47200
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 151.079727485
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2,3-dihydro-1H-inden-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C1N)C=CC(=C2)F

Technology Process of 5-Fluoro-2,3-dihydro-1H-inden-1-amine

There total 5 articles about 5-Fluoro-2,3-dihydro-1H-inden-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-fluoro-1-indanone oxime (148960-32-1) → 5-fluoro-2,3-dihydro-1H-inden-1-amine (148960-33-2,148960-39-8,864268-27-9,1114333-11-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; acetic acid;

Reference yield: 65.5%

(Z)-5-fluoro-2,3-dihydro-1H-inden-1-one oxime → 5-fluoro-2,3-dihydro-1H-inden-1-amine (148960-33-2,148960-39-8,864268-27-9,1114333-11-7)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; at 20 ℃; for 12h;

Reference yield: 45.0%

5-fluoro-1-indanone (700-84-5) → 5-fluoro-2,3-dihydro-1H-inden-1-amine (148960-33-2,148960-39-8,864268-27-9,1114333-11-7)

Guidance literature:

5-fluoro-1-indanone; With titanium(IV) isopropylate; ammonia; In isopropyl alcohol; at 20 ℃;

With sodium tetrahydroborate; In isopropyl alcohol; at 20 ℃; for 2h;

DOI:10.1002/chir.22856

upstream raw materials:

5-fluoro-1-indanone oxime

zinc

5-fluoro-1-indanone

Downstream raw materials:

(R)-5-fluoro-2,3-dihydro-1H-inden-1-amine