4,6-Difluoro-2,3-dihydro-1H-inden-1-amine

Base Information

• Chemical Name: 4,6-Difluoro-2,3-dihydro-1H-inden-1-amine
• CAS No.: 148960-40-1
• Molecular Formula: C₉H₉F₂N
• Molecular Weight: 169.174
• European Community (EC) Number: 859-189-0
• Mol file: 148960-40-1.mol

Synonyms:4,6-DIFLUORO-2,3-DIHYDRO-1H-INDEN-1-AMINE;148960-40-1;4,6-Difluoro-indan-1-ylamine hydrochloride;1H-INDEN-1-AMINE, 4,6-DIFLUORO-2,3-DIHYDRO-;SCHEMBL4521574;(1R)-4,6-DIFLUORO-2,3-DIHYDRO-1H-INDEN-1-AMINE;MFCD07373917;AKOS005265281;AB38294;AB38296;AB38299;AS-49818;CS-0271275;N10992;EN300-1081942;(1S)-4,6-DIFLUORO-2,3-DIHYDRO-1H-INDEN-1-AMINE

Chemical Property of 4,6-Difluoro-2,3-dihydro-1H-inden-1-amine

Chemical Property:

• PSA: 26.02000
• LogP: 2.61110
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 169.07030562
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

98%min ^*data from raw suppliers

4,6-Difluoro-2,3-dihydro-1H-inden-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C1N)C=C(C=C2F)F

Technology Process of 4,6-Difluoro-2,3-dihydro-1H-inden-1-amine

There total 1 articles about 4,6-Difluoro-2,3-dihydro-1H-inden-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-difluoro-1-indanamine (148960-40-1) → (R)-4,6-difluoroindan-1-ylamine (148960-40-1) + C9H9F2N

Guidance literature:

With ChiralPak T₃₀₄ column; In acetonitrile; Resolution of racemate;

Reference yield:

4,6-difluoro-1-indanamine (148960-40-1) → (R)-4,6-difluoroindan-1-ylamine (148960-40-1) + C9H9F2N

Guidance literature:

With ChiralPak T₃₀₄ column; In acetonitrile; Resolution of racemate;

Reference yield:

nicotinic acid (59-67-6) + (R)-4,6-difluoroindan-1-ylamine (148960-40-1) + benzaldehyde (100-52-7) → N-[(R)-carbamoylphenylmethyl]-N-[(R)-4,6-difluoroindan-1-yl]nicotinamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 1 h / 60 °C

1.2: 60 °C

2.1: hydrogenchloride / water; tetrahydrofuran; 1,4-dioxane / 1.5 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: |Ugi Condensation / 1.2: |Ugi Condensation;

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