tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate
CAS No.:149377-19-5
Molecular Formula:C16H23 N O3
Molecular Weight:277.364
Hs Code.:2933399090
European Community (EC) Number:882-061-0
DSSTox Substance ID:DTXSID80598551
Nikkaji Number:J3.464.705D
Wikidata:Q82494321
Mol file:149377-19-5.mol

Synonyms:149377-19-5;1-Boc-4-p-hydroxyphenylpiperidine;tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate;1-Boc-4-Hydroxyphenylpiperidine;MFCD09261337;tert-Butyl 4-(4-hydroxyphenyl)-piperidine-1-carboxylate;4-(4-HYDROXY-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-boc-4-(4-hydroxyphenyl)piperidine;SCHEMBL3854559;DTXSID80598551;CUUQNEXFGPWNPJ-UHFFFAOYSA-N;ZFA37719;AKOS010255287;AB50117;AS-36977;SY040890;DB-063801;CS-0171752;1-Boc-4-p-hydroxyphenylpiperidine, AldrichCPR;EN300-3379078;A808885;A1-50858;tert-Butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate;Z730521650;1-Piperidinecarboxylic acid, 4-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester

Suppliers and Price of tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Boc-4-P-Hydroxyphenylpiperidine
100mg
$ 65.00

Matrix Scientific
tert-Butyl4-(4-hydroxyphenyl)-piperidine-1-carboxylate 97%
25g
$ 3716.00

Matrix Scientific
tert-Butyl4-(4-hydroxyphenyl)-piperidine-1-carboxylate 97%
5g
$ 1239.00

Crysdot
tert-Butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate 97%
250mg
$ 88.00

Crysdot
tert-Butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate 97%
1g
$ 250.00

Crysdot
tert-Butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate 97%
5g
$ 705.00

Chemenu
tert-butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate 97%
1g
$ 355.00

American Custom Chemicals Corporation
1-BOC-4-P-HYDROXYPHENYLPIPERIDINE 95.00%
1G
$ 829.52

Alichem
tert-Butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate
1g
$ 414.20

Alichem
tert-Butyl4-(4-hydroxyphenyl)piperidine-1-carboxylate
5g
$ 727.65

Total 15 raw suppliers

Chemical Property of tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate

Chemical Property:

Vapor Pressure:3.24E-07mmHg at 25°C
Refractive Index:1.541
Boiling Point:407.3°Cat760mmHg
PKA:10.15±0.30(Predicted)
Flash Point:200.1°C
PSA：49.77000
Density:1.121g/cm³
LogP:3.44460
Storage Temp.:2-8°C
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:277.16779360
Heavy Atom Count:20
Complexity:321

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-P-Hydroxyphenylpiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)C2=CC=C(C=C2)O

Technology Process of tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate

There total 17 articles about tert-Butyl 4-(4-hydroxyphenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1869912-48-0
4-(piperidine-4-yl)phenol hydrobromide

: 149377-19-5
4-(4-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 4-(piperidine-4-yl)phenol hydrobromide; With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

di-tert-butyl dicarbonate; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.6b00070

Reference yield: 84.0%

: 541-16-2
t-butyl malonate

: 1869912-48-0
4-(piperidine-4-yl)phenol hydrobromide

: 149377-19-5
4-(4-hydroxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: 4-(piperidine-4-yl)phenol hydrobromide; With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

t-butyl malonate; In dichloromethane; at 20 ℃; for 2h;