6-(Dimethylamino)nicotinaldehyde

Base Information

• Chemical Name: 6-(Dimethylamino)nicotinaldehyde
• CAS No.: 149805-92-5
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• Hs Code.: 2933399090
• European Community (EC) Number: 840-999-8
• DSSTox Substance ID: DTXSID40459715
• Wikidata: Q82283540
• Mol file: 149805-92-5.mol

Synonyms:6-(DIMETHYLAMINO)NICOTINALDEHYDE;149805-92-5;6-(dimethylamino)pyridine-3-carbaldehyde;2-(N,N-DIMETHYLAMINO)PYRIDINE-5-CARBOXALDEHYDE;3-PYRIDINECARBOXALDEHYDE, 6-(DIMETHYLAMINO)-;MFCD08272100;SCHEMBL934755;2-dimethylamino-5-formylpyridine;DTXSID40459715;IRDPUZWWWIDFQX-UHFFFAOYSA-N;6-(dimethyl-amino)-nicotinaldehyde;ZFA80592;AKOS005072130;AB44362;CB-0745;SY040848;6-(dimethylamino)nicotinaldehyde, AldrichCPR;BB 0260283;CS-0054399;FT-0680891;3-NITRO-2-PYRROLIDIN-1-YL-BENZOICACID;EN300-117826;J-008625;J-518069;Z1162448666

Chemical Property of 6-(Dimethylamino)nicotinaldehyde

Chemical Property:

• Vapor Pressure: 0.00267mmHg at 25°C
• Melting Point: 57-59°
• Refractive Index: 1.602
• Boiling Point: 286.2°C at 760 mmHg
• PKA: 5.44±0.10(Predicted)
• Flash Point: 126.9°C
• PSA: 33.20000
• Density: 1.135g/cm³
• LogP: 0.96010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

97% ^*data from raw suppliers

6-(Dimethylamino)nicotinaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C1=NC=C(C=C1)C=O

Technology Process of 6-(Dimethylamino)nicotinaldehyde

There total 7 articles about 6-(Dimethylamino)nicotinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.6%

5-bromo-2-dimethylaminopyridine (26163-07-5) + 2,3-dimethyl-2,3-diaminobutane (20485-44-3) → 6-(dimethylamino)nicotine-3-carboxaldehyde (149805-92-5)

Guidance literature:

In diethyl ether; N,N-dimethyl-formamide;

Reference yield: 68.0%

6-chloronicotinylaldehyde (23100-12-1) + dimethyl amine (124-40-3) → 6-(dimethylamino)nicotine-3-carboxaldehyde (149805-92-5)

Guidance literature:

In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 61.0%

N'-(5-cyanopyridin-2-yl)-N,N-dimethylformamidine (154924-17-1) → 6-(dimethylamino)nicotine-3-carboxaldehyde (149805-92-5)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

upstream raw materials:

5-bromo-2-dimethylaminopyridine

N,N-dimethyl-formamide

2-(Dimethylamino)pyridine

2,3-dimethyl-2,3-diaminobutane

Downstream raw materials:

tert-butyl (4-{(E)-2-[6-(dimethylamino)pyridin-3-yl]vinyl}phenyl)methylcarbamate

(E)-5-(2,6-dichlorostyryl)-2-(N,N-dimethylamino)pyridine

(E)-5-(2-chloro-6-fluorostyryl)-2-(N,N-dimethylamino)pyridine

(E)-5-(2,6-difluorostyryl)-2-(N,N-dimethylamino)pyridine