Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI)

Base Information

Chemical Name:Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI)
CAS No.:149952-37-4
Molecular Formula:C8H6 F N O
Molecular Weight:151.14
Hs Code.:
Mol file:149952-37-4.mol

Synonyms:Benzeneacetonitrile,4-fluoro-a-hydroxy-, (R)-;(+)-2-Hydroxy-2-(4-fluorophenyl)acetonitrile

Suppliers and Price of Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI)

Chemical Property:

PSA：44.02000
LogP:1.38268

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI)

There total 14 articles about Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 74-90-8
hydrogen cyanide

: 459-57-4
4-fluorobenzaldehyde

: 149952-37-4,176485-58-8
(R)-2-(4-fluorophenyl)-2-hydroxyacetonitrile

Guidance literature:: With hydroxynitrile lyase isozyme 5 from Prunus communis; In tert-butyl methyl ether; at 25 ℃; for 7h; pH=5; Enzymatic reaction;
DOI:10.1002/adsc.201601332

Reference yield: 75.0%

: 7677-24-9
trimethylsilyl cyanide

: 459-57-4
4-fluorobenzaldehyde

: 149952-37-4,176485-58-8
(R)-2-(4-fluorophenyl)-2-hydroxyacetonitrile

Guidance literature:: 4-fluorobenzaldehyde; With (S)-[1,1']-binaphthalenyl-2,2'-diol; lithium isopropoxide; In toluene; for 0.166667h; Cooling with acetone-dry ice; Inert atmosphere;

trimethylsilyl cyanide; In toluene; for 1.25h; Cooling; Inert atmosphere;

With hydrogenchloride; In methanol; toluene; at 20 ℃; Inert atmosphere;