Pentanoic acid, 2-hydroxy-4-oxo-, (2S)- (9CI)

Base Information

• Chemical Name: Pentanoic acid, 2-hydroxy-4-oxo-, (2S)- (9CI)
• CAS No.: 150337-72-7
• Molecular Formula: C₅H₈O₄
• Molecular Weight: 132.116
• Mol file: 150337-72-7.mol

Synonyms:Pentanoicacid, 2-hydroxy-4-oxo-, (S)-

Chemical Property of Pentanoic acid, 2-hydroxy-4-oxo-, (2S)- (9CI)

Chemical Property:

• Boiling Point: 325.9±22.0 °C(Predicted)
• PKA: 3.84±0.23(Predicted)
• PSA: 74.60000
• Density: 1.311±0.06 g/cm3(Predicted)
• LogP: -0.58900

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentanoic acid, 2-hydroxy-4-oxo-, (2S)- (9CI)

There total 1 articles about Pentanoic acid, 2-hydroxy-4-oxo-, (2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

acetone (67-64-1) + Glyoxilic acid (298-12-4) → (2S)-2-hydroxy-4-oxopentanoic acid (150337-72-7) + (R)-2-hydroxy-4-oxopentanoic acid (150337-73-8)

Guidance literature:

With N-[(1S)-2'-[[(4-methylphenyl)sulfonyl]amino][1,1'-binaphthalen]-2-yl]-2-pyrrolidinecarboxamide; water; at 0 ℃;

DOI:10.1055/s-0034-1379546

upstream raw materials:

acetone

Glyoxilic acid

Refernces

• 1、 Moles, Fernando J. N.,Guillena, Gabriela,Najera, Carmen. "Aqueous organocatalyzed aldol reaction of glyoxylic acid for the enantioselective synthesis of α-hydroxy-γ-keto acids". . p. 9963 - 9966. Retrieved 2014/03/21.