Ethanone, 1-[6-[(1S)-1-hydroxyethyl]-2-pyridinyl]- (9CI)

Base Information

• Chemical Name: Ethanone, 1-[6-[(1S)-1-hydroxyethyl]-2-pyridinyl]- (9CI)
• CAS No.: 151221-39-5
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.18914
• Mol file: 151221-39-5.mol

Synonyms:Ethanone,1-[6-(1-hydroxyethyl)-2-pyridinyl]-, (S)-; (S)-(-)-6-Acetyl-a-methyl-2-pyridinemethanol

Chemical Property of Ethanone, 1-[6-[(1S)-1-hydroxyethyl]-2-pyridinyl]- (9CI)

Chemical Property:

• Boiling Point: 276.5±25.0 °C(Predicted)
• PKA: 13.12±0.20(Predicted)
• PSA: 50.19000
• Density: 1.137±0.06 g/cm3(Predicted)
• LogP: 1.33750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[6-[(1S)-1-hydroxyethyl]-2-pyridinyl]- (9CI)

There total 5 articles about Ethanone, 1-[6-[(1S)-1-hydroxyethyl]-2-pyridinyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,6-Diacetylpyridine (1129-30-2) → (R,R)-α,α'-dimethyl-2,6-pyridinedimethanol (143329-85-5) + (S)-1-[6-(1-hydroxyethyl)pyridin-2-yl]ethanone (151221-39-5)

Guidance literature:

With baker's yeast; Sucrose; In water; at 30 ℃; for 144h;

DOI:10.1016/S0957-4166(97)00462-X

Reference yield: 59.0%

2,6-Diacetylpyridine (1129-30-2) → (R,R)-α,α'-dimethyl-2,6-pyridinedimethanol (143329-85-5) + (R,S)-α,α'-dimethyl-2,6-pyridinedimethanol (143394-12-1,774225-98-8) + (S)-1-[6-(1-hydroxyethyl)pyridin-2-yl]ethanone (151221-39-5)

Guidance literature:

With (-)-diisopinocamphenylborane chloride; In diethyl ether; at -25 ℃; for 17h;

DOI:10.1016/0040-4039(96)00708-3

Reference yield:

2,6-Diacetylpyridine (1129-30-2) → (S)-1-[6-(1-hydroxyethyl)pyridin-2-yl]ethanone (151221-39-5)

Guidance literature:

With D-glucose; allyl alcohol; In water; at 35 ℃; for 30h; baker's yeast (Saccharomyces cerevisiae, Type 1);

DOI:10.1016/S0957-4166(00)80237-2

upstream raw materials:

2,6-Diacetylpyridine

1-[6-(1-hydroxyethyl)pyridin-2-yl]ethanone

vinyl acetate

Downstream raw materials:

2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6-(2-methyl-[1,3]dioxolan-2-yl)-pyridine

2-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6-(2-methyl-[1,3]dioxolan-2-yl)-pyridine 1-oxide

1-{6-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-pyridin-2-yl}-ethanone