N-cyclopropylpyrimidin-2-amine

Base Information

• Chemical Name: N-cyclopropylpyrimidin-2-amine
• CAS No.: 151390-00-0
• Molecular Formula: C7H9 N3
• Molecular Weight: 135.16646
• ChEMBL ID: CHEMBL1649907
• DSSTox Substance ID: DTXSID00591640
• Nikkaji Number: J3.591.181B
• Wikidata: Q82485460
• Mol file: 151390-00-0.mol

Synonyms:151390-00-0;Cyclopropyl-pyrimidin-2-yl-amine;N-cyclopropylpyrimidin-2-amine;2-Pyrimidinamine, N-cyclopropyl- (9CI);N-Cyclopropyl-2-pyrimidinamine;SCHEMBL246119;CHEMBL1649907;DTXSID00591640;BGA39000;AKOS008923677;SB55991;AM100279;CS-0447187;EN300-227084;F79947;F8881-7954

Chemical Property of N-cyclopropylpyrimidin-2-amine

Chemical Property:

• PSA: 37.81000
• LogP: 1.12390
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 135.079647300
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

≥95% ^*data from raw suppliers

Cyclopropyl-pyrimidin-2-yl-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1NC2=NC=CC=N2

Technology Process of N-cyclopropylpyrimidin-2-amine

There total 1 articles about N-cyclopropylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloropyrimidine (1722-12-9,1195939-87-7) + Cyclopropylamine (765-30-0) → cyclopropyl(pyrimidin-2-yl)amine (151390-00-0)

Guidance literature:

With potassium phosphate; In water; at 100 ℃; for 2h;

DOI:10.1002/ejoc.201600830

Reference yield: 38.0%

cyclopropyl(pyrimidin-2-yl)amine (151390-00-0) + α-bromoacetophenone (70-11-1) → 1-cyclopropyl-5-phenyl-1H-imidazol-2-ylamine

Guidance literature:

cyclopropyl(pyrimidin-2-yl)amine; α-bromoacetophenone; In acetonitrile; at 130 ℃; for 0.25h; microwave irradiation;

With hydrazine; In acetonitrile; at 100 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1021/ol062421c

Reference yield:

cyclopropyl(pyrimidin-2-yl)amine (151390-00-0) + 4-chlorobenzoylmethyl bromide (536-38-9) → Br(1-)*C15H15ClN3O(1+) (1313613-32-9)

Guidance literature:

With dmap; In acetonitrile; at 80 ℃; for 0.5h; Sealed vial; Microwave irradiation;

DOI:10.1016/j.bmc.2011.04.026

upstream raw materials:

2-chloropyrimidine

Cyclopropylamine

Downstream raw materials:

Br^(1-)*C₁₅H₁₅ClN₃O⁽¹⁺⁾