28179-47-7

Basic information

• Product Name: 5-Aminoisophthalic acid monomethyl ester
• Synonyms: Monomethyl 5-aminoisophthalate;CHEMPACIFIC 41247;3-AMINO-5-(METHOXYCARBONYL)BENZOIC ACID;5-AMINOISOPHTHALIC ACID MONOMETHYL ESTER;5-AMINOISOPHTHALIC ACID MONOMETHYLESTER3-AMINO-5-(METHOXYCARBONYL)BENZOIC ACID;Methyl 3-amino-5-carboxybenzoate, 5-Aminoisophthalic acid monomethyl ester
• CAS NO: 28179-47-7
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17
• Mol File: 28179-47-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 440.418 °C at 760 mmHg
• Flash Point: 220.157 °C
• Appearance: /
• Density: 1.373 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-Aminoisophthalic acid monomethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Aminoisophthalic acid monomethyl ester(28179-47-7)
• EPA Substance Registry System: 5-Aminoisophthalic acid monomethyl ester(28179-47-7)

Safety Data

• Hazardous Substances Data: 28179-47-7(Hazardous Substances Data)

Usage

General Description

5-Aminoisophthalic acid monomethyl ester is a chemical compound that belongs to the family of aminoisophthalic acids. It is a monomethyl ester derivative of aminoisophthalic acid, which is commonly used as a building block in organic synthesis. 5-Aminoisophthalic acid monomethyl ester is a white solid with a molecular formula of C9H9NO4 and a molecular weight of 195.17 g/mol. It is primarily used as an intermediate in the production of pharmaceuticals, dyes, and polymer materials. The monomethyl ester group in this compound makes it more reactive and suitable for various chemical reactions, making it a valuable ingredient in the synthesis of complex organic molecules.

InChI:InChI=1/C9H9NO4/c1-14-9(13)6-2-5(8(11)12)3-7(10)4-6/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 1955-46-0 5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester 

Downstream Products

• 900799-65-7 5-benzyloxycarbonylamino-isophthalic acid monomethyl ester 
• 73334-07-3 iopromide 
• 1429636-94-1 C₂₂H₃₅N₇O₈S*C₂HF₃O₂ 
• 1373965-83-3 monomethyl 5-(n-pentylamino)isophthalate 
• 1373965-82-2 monomethyl 5-(n-propylamino)isophthalate 
• 153203-57-7 3-chloro-5-(methoxycarbonyl)benzoic acid 
• 325981-11-1 3-[(3-Chlorophenyl)carbonylamino]-5-(methoxycarbonyl)benzoic Acid 
• 93116-99-5 3-iodo-5-(methoxycarbonyl)benzoic acid 
• 161796-10-7 3-bromo-5-(methoxycarbonyl)benzoic acid 

Relevant articles and documents

The first ready-to-use benzene-based heterotrifunctional cross-linker for multiple bioconjugation

The synthesis and applications of the first water-soluble benzene derivative bearing a set of three different and orthogonal bioconjugatable groups (aminooxy, azido and thiol) are described. The combined use of a 5-amino isophthalic acid scaffold and unusual acid-labile protecting groups for temporarily masking aminooxy and thiol moieties has enabled the development of a highly convergent approach towards the synthesis of such a trivalent bioconjugation platform in good yields. The potential utility of this ready-to-use cross-linking reagent for creating complex and fragile tri-component (bio)molecular systems was illustrated through (1) the rapid preparation of a three-colour FRET cascade with valuable spectral properties and (2) the luminescent/fluorescent labelling of peptides and peptide- oligonucleotide conjugates. Thus, such (bio)molecular assemblies were readily obtained via a three-step process or in a one-pot manner, both involving oxime ligation, thiol-alkylation (SN2 or Michael addition) and copper-catalysed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) reactions.

PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present application describes modulators of MIP-1 of formula (I) : or stereoisomers or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as set forth above. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators are disclosed.

MACROCYCLIC COMPOUNDS USEFUL AS BACE INHIBITORS

The invention relates to novel macrocyclic compounds of the Formula (I) in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.