2'-O-Methyl-5-methyl-U cep

Base Information

• Chemical Name: 2'-O-Methyl-5-methyl-U cep
• CAS No.: 153631-20-0
• Molecular Formula: C₄₁H₅₁N₄O₉P
• Molecular Weight: 774.851
• DSSTox Substance ID: DTXSID601104318
• Mol file: 153631-20-0.mol

Synonyms:153631-20-0;2'-O-METHYL-5-METHYL-U CEP;2/'-O-METHYL-5-METHYL-U CEP;3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile;GMJRPRHRYILEOK-VNZAIEIISA-N;DTXSID601104318;MFCD08062005;AC-32382;BP-29957;HY-150017;CS-0541601;A929980;5'-O-DMTr-2'-O-methyl-5-methyluridine 3'- CED phosphoramidite;5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-cyanoethyl phosphoramidite;162878-63-9;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-methyluridine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite];Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property of 2'-O-Methyl-5-methyl-U cep

Chemical Property:

• PSA: 160.09000
• LogP: 6.44448
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 18
• Exact Mass: 774.33936621
• Heavy Atom Count: 55
• Complexity: 1290

Purity/Quality:

99%, ^*data from raw suppliers

5?-O-DMT-2?-O-methyl-5-methyluridine3?-CEphosphoramidite ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC
• Isomeric SMILES: CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC

Technology Process of 2'-O-Methyl-5-methyl-U cep

There total 22 articles about 2'-O-Methyl-5-methyl-U cep which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyluridine (153631-19-7) → (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihyd ropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (153631-20-0,168611-14-1,168611-18-5)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; Ambient temperature;

DOI:10.1002/hlca.19950780219

Reference yield: 75.0%

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyluridine (153631-19-7) → (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihyd ropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (153631-20-0,168611-14-1,168611-18-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 4.5h;

DOI:10.1002/jhet.5570300522

Reference yield:

2'-O-Methyl-5-methyluridine (55486-09-4) → (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-methyl-2,4-dioxo-3,4-dihyd ropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (153631-20-0,168611-14-1,168611-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 5 h / Ambient temperature

2: 96 percent / diisopropylammonium-tetrazolide / CH₂Cl₂ / Ambient temperature

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane;

DOI:10.1002/hlca.19950780219

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyluridine

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

D-ribose

Downstream raw materials:

C₄₈H₅₄N₅O₁₇P

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 153631-20-0 2'-O-METHYL-5-METHYL-U CEP

Send

Send

Metric Ton KG G Pound L ML

Send

Send