219775-95-8

Basic information

• Product Name: 1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylMethyl)-
• Synonyms: 1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylMethyl)-
• CAS NO: 219775-95-8
• Molecular Formula: C₁₅H₁₂N₂O₂
• Molecular Weight: 252.26798
• Mol File: 219775-95-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylMethyl)-(219775-95-8)
• EPA Substance Registry System: 1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylMethyl)-(219775-95-8)

Safety Data

• Hazardous Substances Data: 219775-95-8(Hazardous Substances Data)

Usage

General Description

1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylmethyl)- is a chemical compound with a naphthyridine core structure and a hydroxy and phenylmethyl functional group. It is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its potential biological and pharmacological activities. It has been studied for its potential as an anti-tumor, anti-inflammatory, and anti-bacterial agent. Additionally, it has shown potential as an inhibitor of protein kinase C, an enzyme involved in various cellular processes. 1,8-Naphthyridin-2(1H)-one, 4-hydroxy-1-(phenylmethyl)- is under ongoing research for its potential applications in the field of medicine and drug development.

Upstream product

• 6935-27-9 N-benzylpyridin-2-amine 
• 423164-49-2 methyl 2-(N-acetyl-N-benzyl)aminonicotinate 
• 100-46-9 benzylamine 
• 33522-80-4 2-(benzylamino)nicotinic acid 
• 2942-59-8 2-chloronicotinic acid 
• 583031-54-3 1-benzyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl acetate 

Downstream Products

• 583031-57-6 1-benzyl-4-chloro-1,8-naphthyridin-2(1H)-one 
• 33760-71-3 4-phenyl-1,8-naphthyridin-2(1H)-one 
• 178548-28-2 1-benzyl-4-phenyl-1,8-naphthyridin-2(1H)-one 
• 59514-89-5 2,4-dichloro-[1,8]naphthyridine 

Relevant articles and documents

Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an organocatalyzed formal [3 + 3] annulation of quinolinones and MBH 2-naphthoates of nitroolefin

An efficient asymmetric and enantio-swithchable organocatalytic [3 + 3] annulation reaction using MBH-2-naphthoates of nitroalkenes and 4-hydroxyquinolin-2(1H)-ones has been developed. Densely substituted tetrahydropyrano[3,2-c]quinolinones scaffolds with two adjacent stereogenic centers are obtained with high yield (up to 95% yield) and good stereoselectivities (up to >20:1 dr and 96% ee) in an enantio-switchable manner. Furthermore, gram scale synthesis was achieved and the nitro group could easily transform into an amino group without any appreciable loss in the diastereo- and enantioselectivity.

NAPHTHYRIDINE DERIVATIVE

The present invention provides a novel naphthyridine derivative that is effective for relieving pain, less toxic, and also is effective for treating diabetic neuropathy, the derivative being represented by the general formula (1) : wherein R1,