D-Phenylalanine, -ba--methyl-, (-ba-S)- (9CI)

Base Information

• Chemical Name: D-Phenylalanine, -ba--methyl-, (-ba-S)- (9CI)
• CAS No.: 59905-30-5
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Mol file: 59905-30-5.mol

Synonyms:D-Phenylalanine,-bta--methyl-,(-bta-S)-(9CI);D-Phenylalanine, -ba--methyl-, (-ba-S)- (9CI)

Chemical Property of D-Phenylalanine, -ba--methyl-, (-ba-S)- (9CI)

Chemical Property:

• Melting Point: 220 - 222 °C
• Boiling Point: 306.0±30.0 °C(Predicted)
• PKA: 2.24±0.10(Predicted)
• PSA: 63.32000
• Density: 1.158±0.06 g/cm3(Predicted)
• LogP: 1.90230

Purity/Quality:

97% ^*data from raw suppliers

(2R,3S)-2-Amino-3-phenyl-butyricacid 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-Phenylalanine, -ba--methyl-, (-ba-S)- (9CI)

There total 31 articles about D-Phenylalanine, -ba--methyl-, (-ba-S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl (2R,3S)-2-benzamide-3-phenylbutanoate (256442-53-2) → threo-D-(2R,3S)-β-methylphenylalanine (59905-30-5,134235-83-9)

Guidance literature:

methyl (2R,3S)-2-benzamide-3-phenylbutanoate; With hydrogenchloride; acetic acid; at 125 ℃; for 24h;

With methyloxirane; In ethanol; Further stages.; Heating;

DOI:10.1016/j.tet.2003.11.044

Reference yield: 92.0%

(3R,5S)-5-phenyl-3-((S)-1-phenylethyl)morpholin-2-one (1327278-13-6) → threo-D-(2R,3S)-β-methylphenylalanine (59905-30-5,134235-83-9)

Guidance literature:

With 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid; In methanol; water; at 20 ℃; for 24h; under 3040.2 Torr;

DOI:10.1002/asia.201100452

Reference yield:

(2R)-azido-(3S)-phenylbutanoic acid (128677-93-0) → threo-D-(2R,3S)-β-methylphenylalanine (59905-30-5,134235-83-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; acetic acid; for 24h; under 1551.4 Torr; Yield given;

DOI:10.1016/S0040-4020(01)81570-2

upstream raw materials:

(2S,3S)-2-azido-3-phenylbutanoic acid

(2R)-azido-(3S)-phenylbutanoic acid

2-amino-3-methyl-3-phenylpropanoic acid

methyl (2R,3S)-2-benzamide-3-phenylbutanoate

Downstream raw materials:

(2R,3S)-2-bromo-3-phenylbutanoic acid