256442-53-2

Upstream product

• 89141-16-2 (Z)-N-benzoyl-β-methyldidehydrophenylalanine methyl ester 
• 67-56-1 methanol 
• 98-86-2 acetophenone 
• 495-69-2 Hippuric Acid 
• 1199-01-5 2-phenylazlactone 
• 68099-99-0 2-phenyl-4-(1-phenylethylidene)oxazol-5(4H)-one 
• 69015-75-4 (Z)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone 

Downstream Products

• 59850-51-0 (2R,3S)-2-amino-3-phenyl-butyric acid hydrochloride 
• 59905-30-5 threo-D-(2R,3S)-β-methylphenylalanine 

Relevant academic research and scientific papers

IL-17 Ligands And Uses Thereof

Provided herein are novel ligands and pharmaceutical compositions thereof which modulate IL-17A. Also provided are methods for preparing the IL-17A modulators. Such compounds may be useful in the treatment and/or prevention of, for example, inflammation, cancer or autoimmune disease.

Practical stereoselective synthesis of β-branched aα-amino acids through efficient kinetic resolution in the phase-transfer-catalyzed asymmetric alkylations

Phase-transfer-catalyzed alkylation of glycinate Schiff base with racemic secondary alkyl halides proceeded with excellent levels of syn- and enantioselectivities under the influence of chiral quaternary ammonium bromide 1d and 18-crown-6. The alkylation

An efficient and stereodivergent synthesis of threo- and erythro-β-methylphenylalanine. Resolution of each racemic pair by semipreparative HPLC

threo and erythro diastereoisomers of the constrained amino acid (βMe)Phe can be obtained separately on a multigram scale through a three-step synthesis from the corresponding Z and E isomers of 2-phenyl-4(α-phenylethylidene)-5(4H)-oxazolone. The 5(4H)-ox

Investigation into an asymmetric hydrogenation promoted by rhodium-phosphetane complexes

The bis-phosphetanes 1 and 2 have been used as chiral ligands in the rhodium-catalysed hydrogenations of dehydroamino acid derivatives. An unusual increase of the optical yields at high hydrogen pressures has been noticed. Mechanistic implications are dis