3-Bromoimidazo[1,2-a]pyrazine

Base Information

• Chemical Name: 3-Bromoimidazo[1,2-a]pyrazine
• CAS No.: 57948-41-1
• Molecular Formula: C6H4BrN3
• Molecular Weight: 198.022
• Hs Code.: 2933990090
• European Community (EC) Number: 624-078-6
• DSSTox Substance ID: DTXSID90378008
• Wikidata: Q72457087
• Mol file: 57948-41-1.mol

Synonyms:3-bromoimidazo[1,2-a]pyrazine;57948-41-1;IMIDAZO[1,2-A]PYRAZINE, 3-BROMO-;MFCD06245372;3-Bromo-imidazo[1,2-a]pyrazine;SCHEMBL107328;DTXSID90378008;OZNGJOXLTIENCF-UHFFFAOYSA-N;3-bromoimidazo [1.2-a] pyrazine;3-bromoimidazo[1,2-alpha]pyrazine;BCP23144;BBL100399;STL554193;AKOS005254228;CS-W003278;FS-2809;PB32412;3-Bromoimidazo[1,2-a]pyrazine, 96%;AC-29501;SY007256;AM20070369;FT-0648036;EN300-1072848;J-512102

Chemical Property of 3-Bromoimidazo[1,2-a]pyrazine

Chemical Property:

• Melting Point: 191-196 °C
• Refractive Index: 1.751
• PKA: 1.35±0.30(Predicted)
• PSA: 30.19000
• Density: 1.89 g/cm³
• LogP: 1.49180
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 196.95886
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromoimidazo[1,2-a]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CN2C(=CN=C2C=N1)Br

Technology Process of 3-Bromoimidazo[1,2-a]pyrazine

There total 3 articles about 3-Bromoimidazo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

imidazo[1,2-a]pyrazine (274-79-3) → 3-bromoimidazo<1,2-a>pyrazine (57948-41-1)

Guidance literature:

With bromine; sodium acetate; potassium bromide; In methanol; at -10 ℃; for 0.0833333h;

Reference yield: 81.0%

imidazo[1,2-a]pyrazine (274-79-3) → 3,5-dibromoimidazo<1,2-a>pyrazine (63744-21-8) + 5-bromoimidazo<1,2-a>pyrazine (87597-26-0) + 3-bromoimidazo<1,2-a>pyrazine (57948-41-1)

Guidance literature:

With bromine; In ethanol; for 1h; Heating;

DOI:10.1021/jm00368a018

Reference yield:

→ 3-bromoimidazo<1,2-a>pyrazine (57948-41-1)

Guidance literature:

1, NBS;

DOI:10.1021/jo00862a005

upstream raw materials:

imidazo[1,2-a]pyrazine

Refernces

• 1、 Harris, Anthony R.,Nason, Deane M.,Collantes, Elizabeth M.,Xu, Wenjian,Chi, Yushi,Wang, Zhihan,Zhang, Bingzhi,Zhang, Qingjian,Gray, David L.,Davoren, Jennifer E.. "Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy". scheme or table. p. 9063 - 9066. Retrieved 2011/12/03.
• 2、 -. "Imidazo-pyrazine derivatives as ligands for gaba receptors". Page/Page column 9. . Retrieved 2008/06/13.