2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID

Base Information

• Chemical Name: 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID
• CAS No.: 503437-19-2
• Molecular Formula: C7H2Cl2F3NO2
• Molecular Weight: 260
• Hs Code.: 2933399090
• Mol file: 503437-19-2.mol

Synonyms:2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID;IFLAB-BB F2108-0098;RARECHEM AL BO 0730

Chemical Property of 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 79-80°
• Refractive Index: 1.515
• Boiling Point: 318.132°C at 760 mmHg
• Flash Point: 146.201°C
• PSA: 50.19000
• Density: 1.703
• LogP: 3.10540
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Dichloro-4-(trifluoromethyl)nicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID

There total 4 articles about 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,6-dichloro-4-trifluoromethyl-3-pyridine carboxamide (158063-67-3) → 2,6-dichloro-4-trifluoromethylnicotinic acid (503437-19-2)

Guidance literature:

With sulfuric acid; water; sodium nitrite; at 20 - 60 ℃; for 18.25h;

Reference yield: 89.0%

2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile (13600-42-5) → 2,6-dichloro-4-trifluoromethylnicotinic acid (503437-19-2)

Guidance literature:

With sulfuric acid; water; nitric acid; at 70 - 100 ℃; for 1h;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 2,6-dichloro-4-(trifluoromethyl)pyridine (39890-98-7) → 2,6-dichloro-4-trifluoromethylnicotinic acid (503437-19-2)

Guidance literature:

2,6-dichloro-4-(trifluoromethyl)pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1021/jm0304966

upstream raw materials:

carbon dioxide

2,6-dichloro-4-(trifluoromethyl)pyridine

2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile

2,6-dichloro-4-trifluoromethyl-3-pyridine carboxamide

Downstream raw materials:

4-(trifluoromethyl)nicotinic acid

Refernces

• 1、 Tsuzuki, Yasunori,Tomita, Kyoji,Shibamori, Koh-Ichiro,Sato, Yuji,Kashimoto, Shigeki,Chiba, Katsumi. "Synthesis and Structure-Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 2". . p. 2097 - 2109. Retrieved 2007/10/03.
• 2、 -. "Antibacterial compounds". Page 40. . Retrieved 2010/02/03.