3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R,4S)-rel- (9CI)

Base Information

• Chemical Name: 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R,4S)-rel- (9CI)
• CAS No.: 604789-40-4
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.27
• Mol file: 604789-40-4.mol

Synonyms:3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R,4S)-rel- (9CI)

Chemical Property of 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R,4S)-rel- (9CI)

Chemical Property:

• PSA: 61.72000
• LogP: 0.26010

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R,4S)-rel- (9CI)

There total 120 articles about 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3R,4S)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3S,4S)-N-benzyl-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine (165877-97-4) → (2R,3S,4S)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine (27958-06-1,604789-37-9,604789-40-4,736097-79-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 8h; under 3620.13 Torr;

DOI:10.1002/ejoc.200300091

Reference yield: 90.0%

benzyl (2R,3R,4R)-3,4-dihydroxy-2-(4-methoxybenzyl)-pyrrolidine-1-carboxylate (24150-14-9) → (2R,3R,4R)-2-(4-methoxybenzyl)pyrrolidine-3,4-diol (853092-30-5,604789-37-9,604789-40-4,736097-79-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tetasy.2011.01.021

Reference yield: 83.0%

(2S,3R,4R)-2-(4-methoxybenzyl)-3,4-bis-benzyloxypyrrolidine → (2S,3R,4R)-3,4-dihydroxy-2-(4-methoxybenzyl)pyrrolidine (19713-95-2,22862-73-3,27958-06-1,604789-37-9,604789-40-4,736097-79-3)

Guidance literature:

With boron trichloride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.carres.2020.107988

upstream raw materials:

(2R,3S,4S)-3,4-bis(benzyloxy)-2-(4-methoxybenzyl)-pyrrolidine

(2R,3S,4S)-2-(4-methoxybenzyl)-3,4-O-bis-(methoxymethyl)pyrrolidine

Acetic acid (3R,4S,5R)-4-hydroxy-5-(4-methoxy-benzyl)-2-oxo-pyrrolidin-3-yl ester

(3R,4S,5R)-N-Benzyl-3,4-dihydroxy-5-p-anisyl-pyrrolidon-2

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