3-butyl-2-hydroxy-1-phenylquinolin-4(1H)-one

Base Information

• Chemical Name: 3-butyl-2-hydroxy-1-phenylquinolin-4(1H)-one
• CAS No.: 97355-56-1
• Molecular Formula: C19H19 N O2
• Molecular Weight: 293.3597
• Mol file: 97355-56-1.mol

Synonyms:Carbostyril,3-butyl-4-hydroxy-1-phenyl- (7CI);3-Butyl-4-hydroxy-1-phenyl-1,2-dihydroquinolin-2-one

Chemical Property of 3-butyl-2-hydroxy-1-phenylquinolin-4(1H)-one

Chemical Property:

• Vapor Pressure: 5.04E-08mmHg at 25°C
• Boiling Point: 426.2°C at 760 mmHg
• Flash Point: 211.6°C
• Density: 1.198g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-butyl-2-hydroxy-1-phenylquinolin-4(1H)-one

There total 9 articles about 3-butyl-2-hydroxy-1-phenylquinolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

diphenylamine (122-39-4) + diethyl butylmalonate (133-08-4) → 3-butyl-4-hydroxy-1-phenylquinolin-2(1H)-one (97355-56-1)

Guidance literature:

at 250 ℃; for 8h;

DOI:10.1007/BF00816857

Reference yield: 61.0%

cis-3-butyl-3,4-dihydro-3,4-dihydroxy-1-phenylquinolin-2(1H)-one → 3-butyl-4-hydroxy-1-phenylquinolin-2(1H)-one (97355-56-1) + 4-butyl-3-hydroxy-1-phenylquinolin-2(1H)-one

Guidance literature:

With sulfuric acid; at 20 ℃; for 1h; Cooling with ice;

DOI:10.1002/hlca.201300074

Reference yield: 54.0%

C21H20N2O2S → 3a-butyl-5-phenyl[1,3]thiazolo[5,4-c]quinoline-2,4(3aH,5H)-dione + 3-butyl-4-hydroxy-1-phenylquinolin-2(1H)-one (97355-56-1)

Guidance literature:

With phosphorus pentoxide; sulfuric acid; acetic acid; at 20 ℃; for 1h;

DOI:10.1002/hlca.201200049

upstream raw materials:

diphenylamine

diethyl butylmalonate

methanol

sodium cyanide

Downstream raw materials:

3-butyl-3-chloro-1-phenyl-1H,3H-quinoline-2,4-dione

3-butyl-1,2-dihydro-2-oxo-1-phenylquinolin-4-yl dihydrogen phosphate hydrate

3-butyl-4-chloro-1-phenylquinolin-2-one

3-Butyl-3-hydroxy-1-phenyl-1H-quinoline-2,4-dione