Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI)

Base Information

Chemical Name:Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI)
CAS No.:604741-60-8
Molecular Formula:C19H22N4O3S
Molecular Weight:386.475
Hs Code.:
Mol file:604741-60-8.mol

Synonyms:Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI)

Suppliers and Price of Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI)

Chemical Property:

PSA：76.05000
LogP:3.17650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI)

There total 4 articles about Piperazine, 1-[(4-methoxyphenyl)sulfonyl]-4-(1-methyl-1H-benzimidazol-2-yl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 137898-68-1
1-methyl-2-(1-piperazinyl)-1H-benzimidazole

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 604741-60-8
2-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]-1-methyl-benzimidazole

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2013.07.047

Reference yield:

: 1849-02-1
2-chloro-1-methyl-benzimidazole

: 604741-60-8
2-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]-1-methyl-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: neat (no solvent) / 1 h / 125 °C

2: hydrogen bromide / water / 24 h / 70 °C

3: triethylamine / dichloromethane / 0 - 20 °C

With hydrogen bromide; triethylamine; In dichloromethane; water;
DOI:10.1016/j.bmcl.2013.07.047

Reference yield:

: 4857-06-1
2-chloro-1H-benzoimidazole

: 604741-60-8
2-[4-(4-methoxyphenyl)sulfonylpiperazin-1-yl]-1-methyl-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / 2 h / 20 °C

2: neat (no solvent) / 1 h / 125 °C

3: hydrogen bromide / water / 24 h / 70 °C

4: triethylamine / dichloromethane / 0 - 20 °C

With hydrogen bromide; triethylamine; sodium hydroxide; In dichloromethane; water;
DOI:10.1016/j.bmcl.2013.07.047