1H-Indene-4-carboxaldehyde,2,3-dihydro-7-hydroxy-6-methyl-(9CI)

Base Information

• Chemical Name: 1H-Indene-4-carboxaldehyde,2,3-dihydro-7-hydroxy-6-methyl-(9CI)
• CAS No.: 575504-30-2
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• Hs Code.: 2912491000
• Mol file: 575504-30-2.mol

Synonyms:1H-Indene-4-carboxaldehyde,2,3-dihydro-7-hydroxy-6-methyl-(9CI)

Chemical Property of 1H-Indene-4-carboxaldehyde,2,3-dihydro-7-hydroxy-6-methyl-(9CI)

Chemical Property:

• Vapor Pressure: 0.000125mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 325°C at 760 mmHg
• Flash Point: 137.9°C
• PSA: 37.30000
• Density: 1.216g/cm³
• LogP: 2.00180
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

7-Hydroxy-6-methyl-2,3-dihydro-1h-indene-4-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indene-4-carboxaldehyde,2,3-dihydro-7-hydroxy-6-methyl-(9CI)

There total 12 articles about 1H-Indene-4-carboxaldehyde,2,3-dihydro-7-hydroxy-6-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.46%

5-methyl-2,3-dihydro-1H-inden-4-ol (20294-31-9) + hexamethylenetetramine (100-97-0) → 7-hydroxy-6-methyl-2,3-dihydro-1H-indene-4-carbaldehyde (575504-30-2)

Guidance literature:

With acetic acid; trifluoroacetic acid; at 95 ℃; for 10h; Cooling;

Reference yield:

5-methyl-2,3-dihydro-1H-inden-4-ol (20294-31-9) → 7-hydroxy-6-methyl-2,3-dihydro-1H-indene-4-carbaldehyde (575504-30-2)

Guidance literature:

With hexamethylenetetramine; In trifluoroacetic acid; at 90 ℃; for 12h;

Reference yield:

4-hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one (1092553-17-7) → 7-hydroxy-6-methyl-2,3-dihydro-1H-indene-4-carbaldehyde (575504-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium on activated carbon / methanol / 5 h / 55 - 60 °C / 10343.2 - 12929 Torr

2: trifluoroacetic acid / 6 h / 25 - 90 °C

With hydrogen; trifluoroacetic acid; palladium on activated carbon; In methanol;

upstream raw materials:

5-methyl-2,3-dihydro-1H-inden-4-ol

hexamethylenetetramine

2-methoxy-3-methylbenzaldehyde

8-methylcoumarin

Downstream raw materials:

7-Methoxy-6-methyl-indan-4-carboxaldehyde

3-{4-[(7-hydroxy-6-methylindan-4-yl)methyl]-3,5-dimethyl-1H-pyrazol-1-yl}propionic acid