2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide

Base Information

Chemical Name:2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide
CAS No.:564446-18-0
Molecular Formula:C14H12FNO2
Molecular Weight:245.2489832
Hs Code.:
DSSTox Substance ID:DTXSID60361220
Wikidata:Q82143450
Mol file:564446-18-0.mol

Synonyms:564446-18-0;2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide;Benzamide, 2-fluoro-N-(2-hydroxy-4-methylphenyl)- (9CI);DTXSID60361220;AKOS001414125;Z33452122;Benzamide,2-fluoro-N-(2-hydroxy-4-methylphenyl)-(9ci)

Suppliers and Price of 2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide

Chemical Property:

Melting Point:164 °C
Boiling Point:305.2±42.0 °C(Predicted)
PKA:9.16±0.40(Predicted)
PSA：49.33000
Density:1.309±0.06 g/cm3(Predicted)
LogP:3.16500
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:245.08520679
Heavy Atom Count:18
Complexity:298

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C=C1)NC(=O)C2=CC=CC=C2F)O

Technology Process of 2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide

There total 2 articles about 2-fluoro-N-(2-hydroxy-4-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2835-98-5
2-Hydroxy-4-methylanilin

: 393-52-2
2-Fluorobenzoyl chloride

: 564446-18-0
2-fluoro-N-(2-hydroxy-4-methylphenyl)-benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm051008s

Reference yield:

: 445-29-4
o-fluoro-benzoic acid

: 564446-18-0
2-fluoro-N-(2-hydroxy-4-methylphenyl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Heating

2: Et₃N / tetrahydrofuran / 0 - 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm051008s