3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine

Base Information

Chemical Name:3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine
CAS No.:503184-34-7
Molecular Formula:C7H5F3INO
Molecular Weight:303.023
Hs Code.:2933399090
DSSTox Substance ID:DTXSID50698956
Nikkaji Number:J1.845.475K
Wikidata:Q82629564
Mol file:503184-34-7.mol

Synonyms:3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine;503184-34-7;SCHEMBL5391265;DTXSID50698956;AT20131;2-(Trifluoromethyl)-3-iodo-6-methoxypyridine

Suppliers and Price of 3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine
500mg
$ 1260.00

Medical Isotopes, Inc.
3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine
500 mg
$ 2200.00

Medical Isotopes, Inc.
3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine
50 mg
$ 650.00

Crysdot
3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine 95+%
1g
$ 510.00

Chemenu
3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine 95%
1g
$ 482.00

Chemcia Scientific
3-Iodo-6-methoxy-2-trifluoromethyl-pyridine 95%
1 G
$ 795.00

American Custom Chemicals Corporation
3-IODO-6-METHOXY-2-TRIFLUOROMETHYL PYRIDINE 95.00%
5MG
$ 504.87

Total 8 raw suppliers

Chemical Property of 3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine

Chemical Property:

Vapor Pressure:0.081mmHg at 25°C
Refractive Index:1.515
Boiling Point:234.495°C at 760 mmHg
PKA:-3.32±0.22(Predicted)
Flash Point:95.619°C
PSA：22.12000
Density:1.868g/cm³
LogP:2.71360
Storage Temp.:2-8°C(protect from light)
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:302.93680
Heavy Atom Count:13
Complexity:176

Purity/Quality:

97% ^*data from raw suppliers

3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=NC(=C(C=C1)I)C(F)(F)F
Uses 3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine is used in the synthesis of biologically active compounds containing a trifluoromethyl moiety.

Technology Process of 3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine

There total 3 articles about 3-Iodo-6-methoxy-2-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 727993-34-2
6-methoxy-2-(trifluoromethyl)pyridin-3-amine

: 503184-34-7
3-iodo-6-methoxy-2-(trifluoromethyl)pyridine

Guidance literature:: 6-methoxy-2-(trifluoromethyl)pyridin-3-amine; With sulfuric acid; sodium nitrite; In water; at 0 - 20 ℃; for 2h;

With potassium iodide; In water; at 60 ℃; for 3h;

Reference yield:

: 38533-61-8
2-chloro-6-methoxy-3-nitropyridine

: 503184-34-7
3-iodo-6-methoxy-2-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuI; KF / dimethylformamide / 5 h / 125 - 130 °C

2.1: Na₂S₂O₄; aq. NH₃ / dioxane / 48 h / 25 °C

3.1: NaNO₂; aq. HCl

3.2: aq. KI / cyclohexane

With hydrogenchloride; potassium fluoride; ammonium hydroxide; copper(l) iodide; sodium dithionite; sodium nitrite; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00835-1

Reference yield:

: 727993-33-1
6-methoxy-3-nitro-2-(trifluoromethyl)pyridine

: 503184-34-7
3-iodo-6-methoxy-2-(trifluoromethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na₂S₂O₄; aq. NH₃ / dioxane / 48 h / 25 °C

2.1: NaNO₂; aq. HCl

2.2: aq. KI / cyclohexane

With hydrogenchloride; ammonium hydroxide; sodium dithionite; sodium nitrite; In 1,4-dioxane;
DOI:10.1016/S0960-894X(02)00835-1