Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel-

Base Information

Chemical Name:Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel-
CAS No.:554411-08-4
Molecular Formula:C16H22N2O
Molecular Weight:258.36
Hs Code.:
Mol file:554411-08-4.mol

Synonyms:Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel-

Suppliers and Price of Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel-

Chemical Property:

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Technology Process of Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel-

There total 6 articles about Benzamide, N-[(2R,6R)-3,6-dihydro-2-methyl-6-propyl-1(2H)-pyridinyl]-, rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 17408-47-8
2-methyl-N-(benzoylimino)pyridinium ylide

: 2234-82-4
1-propylmagnesium chloride

: 554411-08-4,554411-07-3
N-(trans-2-methyl-6-propyl-3,6-dihydropyridin-1(2H)-yl)benzamide

: 554411-08-4,554411-07-3
N-(cis-2-methyl-6-propyl-3,6-dihydropyridin-1(2H)-yl)benzamide

Guidance literature:: 2-methyl-N-(benzoylimino)pyridinium ylide; 1-propylmagnesium chloride; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In diethyl ether; dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/ja0348647

Reference yield: 61.0%

: 17408-47-8
2-methyl-N-(benzoylimino)pyridinium ylide

: 2234-82-4
1-propylmagnesium chloride

: 554411-08-4,554411-07-3
N-(trans-2-methyl-6-propyl-3,6-dihydropyridin-1(2H)-yl)benzamide

: 554411-08-4,554411-07-3
N-(cis-2-methyl-6-propyl-3,6-dihydropyridin-1(2H)-yl)benzamide

Guidance literature:: 2-methyl-N-(benzoylimino)pyridinium ylide; 1-propylmagnesium chloride; In diethyl ether; dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In diethyl ether; dichloromethane; at -78 ℃; for 2h;
DOI:10.1021/ja0348647

Reference yield:

: 109-06-8
α-picoline

: 554411-08-4,554411-07-3
N-(trans-2-methyl-6-propyl-3,6-dihydropyridin-1(2H)-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. H₂NOSO₃H / tetrahydrofuran / 0.5 h

1.2: 58 percent / aq. NaOH / tetrahydrofuran / 20 h / 20 °C

2.1: CH₂Cl₂; diethyl ether / 0.5 h / 20 °C

2.2: NaBH(OAc)3 / CH₂Cl₂; diethyl ether / 2 h / -78 °C

With hydroxylamine-O-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja0348647