(R)-tert-butyl 3-(2-Hydroxyethyl)piperazine-1-carboxylate

Base Information

• Chemical Name: (R)-tert-butyl 3-(2-Hydroxyethyl)piperazine-1-carboxylate
• CAS No.: 1272421-10-9
• Molecular Formula: C11H22N2O3
• Molecular Weight: 230.30398
• Mol file: 1272421-10-9.mol

Synonyms:(R)-tert-butyl 3-(2-Hydroxyethyl)piperazine-1-carboxylate;(3R)-3-(2-Hydroxyethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

Chemical Property of (R)-tert-butyl 3-(2-Hydroxyethyl)piperazine-1-carboxylate

Chemical Property:

• Boiling Point: 352.2±22.0 °C(Predicted)
• PKA: 15.11±0.10(Predicted)
• PSA: 61.80000
• Density: 1.067±0.06 g/cm3(Predicted)
• LogP: 0.84440
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl3-(2-hydroxyethyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-butyl 3-(2-Hydroxyethyl)piperazine-1-carboxylate

There total 7 articles about (R)-tert-butyl 3-(2-Hydroxyethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-(piperazin-2-yl)ethan-1-ol (660862-46-4) + di-tert-butyl dicarbonate (24424-99-5) → (R)-tert-butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate (1272421-10-9)

Guidance literature:

In methanol; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2018.04.030

Reference yield:

(R)-dimethyl 2-(2-chloroacetamido)succinate (1485770-18-0) → (R)-tert-butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate (1272421-10-9)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 124 h / 65 °C / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Heating

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2844.39 - 3361.55 Torr / Autoclave

4: methanol / 18 h / 0 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; acetonitrile;

DOI:10.1016/j.tetlet.2018.04.030

Reference yield:

(R)-methyl 2-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate → (R)-tert-butyl 3-(2-hydroxyethyl)piperazine-1-carboxylate (1272421-10-9)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Heating

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2844.39 - 3361.55 Torr / Autoclave

3: methanol / 18 h / 0 - 20 °C

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2018.04.030

upstream raw materials:

(R)-dimethyl 2-(2-chloroacetamido)succinate

(R)-2-(4-benzylpiperazin-2-yl)ethanol

(R)-2-(piperazin-2-yl)ethan-1-ol

di-tert-butyl dicarbonate