2-methyl-2-methylsulfonyloxy-propane

Base Information

• Chemical Name: 2-methyl-2-methylsulfonyloxy-propane
• CAS No.: 16427-41-1
• Molecular Formula: C5H12 O3 S
• Molecular Weight: 152.214
• Hs Code.: 2904100000
• Mol file: 16427-41-1.mol

Synonyms:Methanesulfonicacid, tert-butyl ester (7CI,8CI); tert-Butyl mesylate

Chemical Property of 2-methyl-2-methylsulfonyloxy-propane

Chemical Property:

• Vapor Pressure: 0.109mmHg at 25°C
• Boiling Point: 228.7°C at 760 mmHg
• Flash Point: 92.1°C
• PSA: 51.75000
• Density: 1.098g/cm³
• LogP: 1.84190

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-2-methylsulfonyloxy-propane

There total 3 articles about 2-methyl-2-methylsulfonyloxy-propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanesulfonyl chloride (124-63-0) + tert-butyl alcohol (75-65-0) → tert-butyl mesylate (16427-41-1)

Guidance literature:

With triethylamine; In dichloromethane; at -15 ℃; for 1h; Green chemistry;

DOI:10.1039/c8ob01896k

Reference yield:

O,O-diethyl S-methyl phosphorothioate (2404-05-9) + tert-butyl alcohol (75-65-0) → methanesulfonic acid (75-75-2,98527-29-8) + Diethyl phosphate (598-02-7) + (2-methyl-2-propyl) diethyl phosphate (13232-08-1) + tert-butyl mesylate (16427-41-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid;

Reference yield:

→ tert-butyl mesylate (16427-41-1)

Guidance literature:

tert.-Butanol, Methylsulfonylchlorid (Pyridin/Eiskuehlung);

upstream raw materials:

methanesulfonyl chloride

tert-butyl alcohol

O,O-diethyl S-methyl phosphorothioate

Downstream raw materials:

(E)-N-(1,3-diphenylallyl)-2-methylpropane-2-sulfonamide

C₉H₁₁O₂S₂

Refernces

• 1、 Culshaw, Peter N.,Walton, John C.. "Sulphonate Esters as Sources of Sulphonyl Radicals; Ring-closure Reactions of Alk-4- and -5-enesulphonyl Radicals". . p. 1201 - 1208. Retrieved 2007/10/02.
• 2、 Segall, Yoffi,Casida, John E.. "REACTION OF PROPOSED PHOSPHOROTHIOLATE S-OXIDE INTERMEDIATES WITH ALCOHOLS". . p. 209 - 212. Retrieved 2007/10/02.