2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-1,5-dihydro-3-hydroxy-

Base Information

• Chemical Name: 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-1,5-dihydro-3-hydroxy-
• CAS No.: 512177-56-9
• Molecular Formula: C₁₈H₂₀FNO₃
• Molecular Weight: 317.36
• Hs Code.: 2933990090
• Mol file: 512177-56-9.mol

Synonyms:2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-1,5-dihydro-3-hydroxy-

Chemical Property of 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-1,5-dihydro-3-hydroxy-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• Boiling Point: 463.649°C at 760 mmHg
• Flash Point: 234.207°C
• PSA: 57.61000
• Density: 1.31g/cm³
• LogP: 3.58730

Purity/Quality:

4-ACETYL-5-CYCLOHEXYL-1-(3-FLUOROPHENYL)-1,5-DIHYDRO-3-HYDROXY-2H-PYRROL-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-1,5-dihydro-3-hydroxy-

There total 2 articles about 2H-Pyrrol-2-one, 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-1,5-dihydro-3-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

meta-fluoroaniline (372-19-0) + ethyl 2,4-diketopentanoate (615-79-2) + cyclohexanecarbaldehyde (2043-61-0) → 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one (512177-56-9)

Guidance literature:

With acetic acid; at 95 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00605

Reference yield:

→ 4-acetyl-5-cyclohexyl-1-(3-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one (512177-56-9)

Guidance literature:

upstream raw materials:

meta-fluoroaniline

ethyl 2,4-diketopentanoate

cyclohexanecarbaldehyde