2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER

Base Information

• Chemical Name: 2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER
• CAS No.: 56752-40-0
• Molecular Formula: C7H12O5
• Molecular Weight: 176.169
• Mol file: 56752-40-0.mol

Synonyms:2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER;Methyl ethyl methoxymalonate

Chemical Property of 2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER

Chemical Property:

• Boiling Point: 223.4±20.0 °C(Predicted)
• PKA: 13.07±0.46(Predicted)
• PSA: 61.83000
• Density: 1.116±0.06 g/cm3(Predicted)
• LogP: -0.26250

Purity/Quality:

99% ^*data from raw suppliers

1-Ethyl 3-Methyl 2-Methoxymalonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER

There total 2 articles about 2-METHOXYPROPANDIOIC ACID ETHYL METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + dimethyl diazomalonate (6773-29-1) → 1-ethyl 3-methyl 2-methoxymalonate (56752-40-0)

Guidance literature:

Irradiation;

Reference yield:

→ 1-ethyl 3-methyl 2-methoxymalonate (56752-40-0)

Guidance literature:

Dimethyldiazomalonat, EtOH/ Licht;

DOI:10.1246/bcsj.48.1951

Reference yield: 65.0%

1-ethyl 3-methyl 2-methoxymalonate (56752-40-0) + 4-nitrobenzamidine hydrochloride (15723-90-7) + sodium methylate (124-41-4) → 6-hydroxy-5-methoxy-2-(4-nitrophenyl)-3H-pyrimidin-4-one (1313720-97-6)

Guidance literature:

1-ethyl 3-methyl 2-methoxymalonate; 4-nitrobenzamidine hydrochloride; sodium methylate; In ethanol; for 8h; Reflux;

With hydrogenchloride; In water; at 0 ℃;

upstream raw materials:

ethanol

dimethyl diazomalonate

Downstream raw materials:

6-hydroxy-5-methoxy-2-(4-nitrophenyl)-3H-pyrimidin-4-one