ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE

Base Information

Chemical Name:ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE
CAS No.:481659-93-2
Molecular Formula:C26H21F3N2O3
Molecular Weight:466.46
Hs Code.:
Mol file:481659-93-2.mol

Synonyms:ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE

Suppliers and Price of ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE

Chemical Property:

PSA：60.33000
LogP:6.36610

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE

There total 2 articles about ETHYL 1-METHYL-5-[4''-(TRIFLUOROMETHYL)BIPHENYL-2-CARBOXAMIDO]INDOLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 84392-17-6
4'-(trifluoromethyl)-2-biphenylcarboxylic acid

: 481659-93-2
ethyl 1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1H-indole-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2007.01.018

Reference yield: 71.8%

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 84392-17-6
4'-(trifluoromethyl)-2-biphenylcarboxylic acid

: 180340-74-3
4'-trifluoromethylbiphenyl-2-carbonyl chloride

: 481659-93-2
ethyl 1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1H-indole-2-carboxylate

Guidance literature:: With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethylbenzamide; In water; ethyl acetate; isopropyl alcohol; toluene;