6-Hydroxyoxymorphone

Base Information

• Chemical Name: 6-Hydroxyoxymorphone
• CAS No.: 483981-19-7
• Molecular Formula: C17H21NO4
• Molecular Weight: 303.35
• NSC Number: 707489
• DSSTox Substance ID: DTXSID301018770
• Nikkaji Number: J3.103.774C
• ChEMBL ID: CHEMBL1968360
• Mol file: 483981-19-7.mol

Synonyms:483981-19-7;6-Hydroxyoxymorphone;6-hydroxy-oxymorphone;6-Hydroxy Oxymorphone;CHEMBL1968360;SCHEMBL19290171;DTXSID301018770;NSC707489;AKOS030240649;NSC-707489;NCI60_038188

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Chemical Property of 6-Hydroxyoxymorphone

Chemical Property:

• Melting Point: 218-239°C
• Boiling Point: 517.6±50.0 °C(Predicted)
• PKA: 9.39±0.60(Predicted)
• PSA: 73.16000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: 0.47490
• Storage Temp.: Controlled Substance, -20°C Freezer
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 303.14705815
• Heavy Atom Count: 22
• Complexity: 501

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C(CCC2(C1CC5=C3C(=C(C=C5)O)O4)O)O
• Isomeric SMILES: CN1CC[C@]23[C@@H]4C(CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O)O
• Uses: A metabolite of Oxymorphone.

Technology Process of 6-Hydroxyoxymorphone

There total 18 articles about 6-Hydroxyoxymorphone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

oxymorphone (76-41-5) → alpha-Oxymorphol (2183-56-4,483981-19-7)

Guidance literature:

With formic acid; triethylamine; In acetonitrile; at 20 ℃; for 24h; Product distribution / selectivity;

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + noroxymorphone (33522-95-1) → alpha-Oxymorphol (2183-56-4,483981-19-7)

Guidance literature:

formaldehyd; noroxymorphone; In acetonitrile; at 20 ℃; for 16h;

With formic acid; triethylamine; In acetonitrile; at 20 ℃; for 24.5h; Product distribution / selectivity;

Reference yield: 92.0%

C19H23NO5 (180989-07-5) → 6β-oxymorphol (54934-75-7,483981-19-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃;

upstream raw materials:

14-hydroxycodeine

14-hydroxydihydrocodeine

oxymorphone

formaldehyd

Downstream raw materials:

5,6-didehydro-3,14-dihydroxy-17-methyl-4,5α-epoxymorphinan

6β-oxymorphamine