Technology Process of 5-ETHOXY-1H-INDAZOLE
There total 1 articles about 5-ETHOXY-1H-INDAZOLE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 24h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C
2: dmap; triethylamine / acetonitrile / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 3 h / Reflux
4: trifluoroacetic acid / dichloromethane / 0.75 h / 20 °C
With
dmap; tetrakis(triphenylphosphine) palladium(0); iodine; sodium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
3: |Suzuki Coupling;
DOI:10.1021/jm4000215
- Guidance literature:
-
Multi-step reaction with 3 steps
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C
2: dmap; triethylamine / acetonitrile / 20 °C
3: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 3 h / Reflux
With
dmap; tetrakis(triphenylphosphine) palladium(0); iodine; sodium carbonate; triethylamine; potassium hydroxide;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
3: |Suzuki Coupling;
DOI:10.1021/jm4000215
