4-methoxy-N-methyl-N-phenylaniline

Base Information

• Chemical Name: 4-methoxy-N-methyl-N-phenylaniline
• CAS No.: 55251-46-2
• Molecular Formula: C14H15NO
• Molecular Weight: 213.279
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID10395717
• Nikkaji Number: J60.174H
• Wikidata: Q82195937
• Mol file: 55251-46-2.mol

Synonyms:4-methoxy-N-methyl-N-phenylaniline;55251-46-2;(4-METHOXY-PHENYL)-METHYL-PHENYL-AMINE;N-(4-methoxyphenyl)-N-methylaniline;N-methyl-N-phenyl-p-anisidine;SCHEMBL5277509;N-Methyl-4-methoxydiphenylamine;4-methoxy-n-methyl diphenylamine;DTXSID10395717;JYNABQRMIKWGTK-UHFFFAOYSA-N;AKOS015964459;SB78822;A830556;J-501423

Chemical Property of 4-methoxy-N-methyl-N-phenylaniline

Chemical Property:

• Boiling Point: 344.9±25.0 °C(Predicted)
• PKA: 1.72±0.32(Predicted)
• PSA: 12.47000
• Density: 1.077±0.06 g/cm3(Predicted)
• LogP: 3.46310
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 193

Purity/Quality:

99.3% ^*data from raw suppliers

4-Methoxy-N-methyl-N-phenylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C1=CC=CC=C1)C2=CC=C(C=C2)OC

Technology Process of 4-methoxy-N-methyl-N-phenylaniline

There total 29 articles about 4-methoxy-N-methyl-N-phenylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

iodobenzene (591-50-4) + 4-methoxy-N,N-dimethylanilne (701-56-4) → N-(4-methoxyphenyl)-N-methylaniline (55251-46-2)

Guidance literature:

With potassium tert-butylate; In 1,4-dioxane; dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0034-1379367

Reference yield: 99.0%

1-bromo-4-methoxy-benzene (104-92-7) + N-methylaniline (100-61-8) → N-(4-methoxyphenyl)-N-methylaniline (55251-46-2)

Guidance literature:

With tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In toluene; for 6h; Ambient temperature;

DOI:10.1021/jo990408i

Reference yield: 99.0%

4-chloromethoxybenzene (623-12-1) + N-methylaniline (100-61-8) → N-(4-methoxyphenyl)-N-methylaniline (55251-46-2)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; di-tert-butylneopentylphosphonium tetrafluoroborate; sodium t-butanolate; In toluene; at 100 ℃; for 18h;

DOI:10.1021/jo060303x

upstream raw materials:

4-anilinophenol

methyl iodide

4-methoxyphenyl triflate

N-methylaniline

Downstream raw materials:

C₂₃H₂₉NO₅