Norfluoxetine

Base Information

• Chemical Name: Norfluoxetine
• CAS No.: 56161-73-0
• Molecular Formula: C₁₆H₁₆F₃NO
• Molecular Weight: 295.304
• Mol file: 56161-73-0.mol

Synonyms:gamma-(4-(Trifluoromethyl)phenoxy)benzenepropanamine;

Chemical Property of Norfluoxetine

Chemical Property:

• Vapor Pressure: 5.21E-06mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 381.1°Cat760mmHg
• Flash Point: 184.3°C
• Density: 1.204g/cm³

Purity/Quality:

≥95% ^*data from raw suppliers

NORFLUOXETINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Norfluoxetine

There total 33 articles about Norfluoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phthalamide-3-(4-trifluormethyl-phenoxy)-3-phenyl-propane → norfluoxetine (83891-03-6,56161-73-0)

Guidance literature:

With methanol; hydrazine; In dichloromethane; at 20 ℃; for 8h;

Reference yield: 96.0%

(S)-3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propionitrile (191729-88-1) → (S)-norfluoxetine (126924-38-7,56161-73-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 65 ℃; for 5h;

DOI:10.1016/S0040-4020(97)00325-6

Reference yield: 90.0%

4-chlorobenzotrifluoride (98-56-6) + (1R)-3-amino-1-phenyl-1-propanol (138750-31-9) → (R)-Norfluoxetine (130194-43-3,56161-73-0)

Guidance literature:

(1R)-3-amino-1-phenyl-1-propanol; With sodium hydride; In dimethyl sulfoxide; at 55 ℃; for 0.5h;

4-chlorobenzotrifluoride; In dimethyl sulfoxide; at 90 ℃; for 1h;

DOI:10.1016/S0040-4039(02)00842-0

upstream raw materials:

1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane

4-chlorobenzotrifluoride

(1R)-3-amino-1-phenyl-1-propanol

styrene

Refernces

• 1、 -. "TREATMENT OF METABOLIC SYNDROME WITH NOVEL AMIDES". Page/Page column 83-85. . Retrieved 2009/07/17.
• 2、 -. "MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS". Page/Page column 148. . Retrieved 2010/10/20.