6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER
• CAS No.: 5043-00-5
• Molecular Formula: C12H9FO2
• Molecular Weight: 204.2
• Hs Code.: 2916399090
• Mol file: 5043-00-5.mol

Synonyms:6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER;METHYL 6-FLUORO-2-NAPHTHOATE;6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER EP

Chemical Property of 6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 87 °C
• Refractive Index: 1.589
• Boiling Point: 307.549°C at 760 mmHg
• Flash Point: 135.332°C
• PSA: 26.30000
• Density: 1.233g/cm³
• LogP: 2.76550
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

Methyl 6-Fluoro-2-naphthoate >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER

There total 10 articles about 6-FLUORO-2-NAPHTHOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 6-(tributylstannyl)-2-naphthoate (1325730-39-9) → methyl 6-fluoro-4-methyl-2-naphthoate (5043-00-5)

Guidance literature:

With silver trifluoromethanesulfonate; In acetone; at 20 ℃; for 0.5h;

DOI:10.1021/acs.orglett.7b03669

Reference yield: 55.0%

(E)-methyl-2-(4-fluorobenzylidene)-5-(triisopropylsilyl)pent-4-ynoate → methyl 6-fluoro-4-methyl-2-naphthoate (5043-00-5)

Guidance literature:

With tetrabutyl ammonium fluoride; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00728

Reference yield:

6-Bromonaphthalen-2-amine (7499-66-3) → methyl 6-fluoro-4-methyl-2-naphthoate (5043-00-5)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) (diazotization), (ii) aq. HPF₆

2: paraffin / 130 - 140 °C

3: Py / dimethylformamide

4: aq. H₂SO₄, AcOH

5: dioxane

With pyridine; sulfuric acid; acetic acid; In 1,4-dioxane; N,N-dimethyl-formamide; paraffin;

DOI:10.1021/ja00978a038

upstream raw materials:

diazomethane

6-fluoro-2-naphthoic acid

6-Bromonaphthalen-2-amine

2-bromo-6-fluoronaphthalene

Downstream raw materials:

6-fluoro-2-naphthoic acid

methyl 6-(4-tolyl)-2-naphthoate